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Composite gel of CMC and collagen synthase inhibitor for preventing adhered Fe crosslinked and its preparation

A technology of collagen synthesis and composite gel, applied in the field of composite gel, can solve the problems of complex extraction and purification of hyaluronic acid, difficulty in high purity, trauma, etc., to achieve enhanced anti-adhesion effect and good biocompatibility , the effect of reducing the cost of medical treatment

Inactive Publication Date: 2007-01-17
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as: Chinese patent "carboxymethyl chitosan / carboxymethyl cellulose anti-surgical adhesion film and its preparation method" (patent application: 03153650.6), but this anti-surgical adhesion film is subject to great restrictions in application, such as peritoneum Between the intestine and the intestine, and between the intestine and the intestine, because the intestine is in constant peristalsis, the isolation membrane is easy to slide, which may cause new trauma to the original healthy and undamaged parts
Chinese patent "Hyaluronic acid gel with medicine and iron ions for anti-adhesion after surgery" (patent application: 03133843.7), due to the high price of hyaluronic acid, the cost of medical treatment for patients is high, and hyaluronic acid is mostly of animal origin , there is an immunogenicity problem in the body, and the extraction and purification process of hyaluronic acid is complicated, it is very difficult to maintain high purity, and there will be heavy metal residues, which will lead to human poisoning after implantation

Method used

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  • Composite gel of CMC and collagen synthase inhibitor for preventing adhered Fe crosslinked and its preparation
  • Composite gel of CMC and collagen synthase inhibitor for preventing adhered Fe crosslinked and its preparation
  • Composite gel of CMC and collagen synthase inhibitor for preventing adhered Fe crosslinked and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1.1 Preparation of Fe 3+ Cross-linked CMC

[0045] a. Add 1000ml of deionized water to carboxymethyl cellulose (5g), configure it as a 0.5% CMC solution by mass, and stir until it dissolves;

[0046] b. FeCl 3 (4.5g) by adding 300ml 1M HCl, it is configured as FeCl with a mass volume concentration of 1.5%. 3 solution;

[0047] c. Add 1M HCl dropwise to the CMC solution while stirring to fully mix the two until the pH value reaches 3;

[0048] d. Take 300ml of solution b and add it dropwise to 1000ml of solution c, and stir thoroughly;

[0049] e. Add 1M NaOH dropwise to the solution in d until the solution becomes a gel and the pH value is 7.5;

[0050] f. Freeze-dry the gel in e and press it into powder;

[0051] g. Put the powder in f into a disinfection cabinet for disinfection;

[0052] 1.2 Preparation of composite gel

[0053] Mix 2g of the powder prepared in 1.1 with 40g of Tranister drug powder, add 10ml of 0.1M sterile PBS, stir well until a uniform gel ...

Embodiment 2

[0055] 2.1 Preparation of Fe 3+ Cross-linked CMC

[0056] a. Add 1000ml of deionized water to carboxymethyl cellulose (50g), configure it as a 5% CMC solution by mass, and stir until it dissolves;

[0057] b. FeCl 3 (5g) Add 200ml of 1.5M HCl to configure FeCl with a mass volume concentration of 2.5% 3 solution;

[0058] c. Add 2M HCl dropwise to the CMC solution while stirring to fully mix the two until the pH value reaches 4;

[0059] d. Take 200ml of solution b and add it dropwise to 1000ml of solution c, and stir thoroughly;

[0060] e. Add 2M NaOH dropwise to the solution in d until the solution becomes a gel and the pH value is 6.8;

[0061] f. Freeze-dry the gel in e and press it into powder;

[0062] g. Put the powder in f into a disinfection cabinet for disinfection;

[0063] 2.2 Preparation of composite gel

[0064] Mix 2g of the powder prepared in 2.1 with 20g of Tranister drug powder, dissolve in 10ml of 0.5M sterile PBS, stir well until a uniform gel syste...

Embodiment 3

[0066] 3.1 Preparation of Fe 3+ Cross-linked CMC

[0067] a. Add 500ml of deionized water to carboxymethyl cellulose (5g), configure it as a 10% CMC solution by mass, and stir until it dissolves;

[0068] b. FeCl 3 (2g) Add 200ml 0.5M HCl to configure FeCl with a mass volume concentration of 10% 3 solution;

[0069] c. Add 1M HCl dropwise to the CMC solution while stirring to fully mix the two until the pH value reaches 3.5;

[0070] d. Take 200ml of solution b and add it dropwise to 500ml of solution c, and stir thoroughly;

[0071] e. Add 0.5M NaOH dropwise to the solution in d until the solution becomes a gel and the pH value is 7.5;

[0072] f. Freeze-dry the gel in e and press it into powder;

[0073] g. Put the powder in f into a disinfection cabinet for disinfection;

[0074] 3.2 Preparation of composite gel

[0075] Mix 2g of the powder prepared in 3.1 with 30g of Tranister drug powder, dissolve it in 10ml of 0.01M sterile PBS, stir well until a uniform gel sys...

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Abstract

An anti-adhesion compound gel for surgical operation is prepared from Fe ion cross-linked CMC, collagen synthetase depressant and PBS solution. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a novel anti-adhesion agent after surgery, in particular to a Fe 3+ Composite gel of cross-linked carboxymethylcellulose with collagen synthase inhibitors. Background technique [0002] The development of anti-adhesion agents originated from the medical profession's concern about post-surgical adhesions. Adhesions increase the difficulty of reoperation and the potential risk of further complications. Therefore, in-depth exploration of the causes of adhesion formation to prevent and reduce postoperative adhesions has become a key research direction in the field of surgery today. At present, there are two commonly used methods for reducing adhesions: 1) direct perfusion of various substances to reduce or inhibit the formation of fibrous connective tissue (Wiseman D. Polymers for the prevention of surgical adhesions. In: Domb AJ, ed. Polymeric site-specific pharmacotherapy.NewYork: John Wiley & Sons, 1994.370~421), but systemic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/717A61K31/195A61K31/519A61K9/00A61P41/00
Inventor 胡刚田维明
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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