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Paramagnetic metal manganese doped multi-complex as magnetic resonance imaging contrast agent

A paramagnetic metal, magnetic resonance imaging technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, etc., can solve the problem of high toxicity, and achieve long-lasting, clinical diagnosis, good thermal stability and water solubility. Effect

Inactive Publication Date: 2006-12-20
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Application Information

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Problems solved by technology

[0005] It has been reported in the literature that metalloporphyrins show obvious enhancement effects on the imaging of the heart, liver and spleen, and are a better choice for organ-selective MRI contrast agents (Inorganic Chemistry Journal Inorg.Chim.Acta, 1998, 106, 275), but more toxic

Method used

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  • Paramagnetic metal manganese doped multi-complex as magnetic resonance imaging contrast agent
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  • Paramagnetic metal manganese doped multi-complex as magnetic resonance imaging contrast agent

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Effect test

Embodiment 1

[0031] Weigh 90g of sodium tungstate and 5g of sodium silicate and dissolve them in 150mL of water, heat to boiling, add 95mL of 4M hydrochloric acid dropwise, keep boiling for 1h, and finally add 35g of potassium chloride solid to obtain α-K 8 SiW 11 o 39 12H 2 O precipitation. Dissolve 6 g of the obtained substance in 30 mL of water, add 4 mL of 0.5 M manganese sulfate dropwise under stirring in a water bath at 40 ° C, filter and add 2 g of potassium chloride after ten minutes, cool and place at about 5 ° C, precipitate crystals, and recrystallize to obtain paramagnetic MRI Contrast Agent K of Metal Manganese Heteropolycomplex 6 wxya 11 o 39 solid, the structure of which is figure 1 a.

Embodiment 2

[0033] Dissolve 50g of sodium tungstate in 180mL of hot water, heat to boiling, slowly add 75mL of 85% phosphoric acid, reflux for 8 hours, the solution is grass green, add bromine water dropwise until pure yellow, cool to room temperature, add 50g of powdered chloride Ammonium gives pale yellow (NH 4 ) 6 [P 2 W 18 o 62 ]·xH 2 O was precipitated, acidified with 1:1 hydrochloric acid, extracted with ether, and evaporated to dryness in a water bath to give light green α-H 6 [P 2 W 18 o 62 ]·xH 2 O. 18gα-H 6 [P 2 W 18 o 62 ]·xH 2 Dissolve O in 75mL of water at 80°C, add 1g of manganese chloride dissolved in a small amount of hot water while stirring, slowly add 12g of potassium acetate hot solution 18mL to adjust the pH value to 7.0, then filter and cool to about 5°C, precipitate crystals and recrystallize Obtained paramagnetic metal manganese heteropoly complex magnetic resonance imaging contrast agent K 8 MnP 2 W 17 o 61 solid, the structure of which is fig...

Embodiment 3

[0035] Dissolve 120g of sodium tungstate in 150mL of water, gradually add 3mL of phosphoric acid and 22mL of glacial acetic acid, and form white precipitate Na 8 HPW 9 o 34 24 hours 2 O, filtered, dried at 800°C, and set aside. Prepared Na 8 HPW 9 o 34 24 hours 2 O was dried at 140°C for 1 hour, 2 g was slowly added to 15 mL of solution containing 0.2366 g of manganese sulfate, the solution turned orange-red under heating and stirring at low temperature, the insoluble matter was filtered off, and 5 g of potassium chloride was added to produce an orange solid precipitate, which was weighed Crystallization of Paramagnetic Metallic Manganese Heteropolycomplex MRI Contrast Agent K 10 mn 4 (H 2 O) 2 (PW 9 o 39 ) 2 solid, the structure of which is figure 1 c.

[0036] The usage of paramagnetic metal manganese heteropoly complex magnetic resonance imaging contrast agent is as follows:

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Abstract

The invention relates to a magnetic resonance imaging contrast agent, which uses paramagnetism manganese heteropoly complex, wherein the inventive contrast agent is the high-stability chelate formed by transition paramagnetism manganese and heteropoly acid or heteropoly acid salt with Keggin or Dawson structure, which has target property and better signal strengthen effect on the liver, kidney, etc. And the inventive chelate can be used in X-ray CT or ultrasonic image contrast.

Description

technical field [0001] The invention relates to a magnetic resonance imaging contrast agent, in particular to a paramagnetic metal manganese heteropoly complex used as a magnetic resonance imaging contrast agent. Background technique [0002] Magnetic resonance imaging (MRI) is an imaging technology that uses the signal generated by the resonance of the atomic nucleus in a magnetic field to reconstruct the image. It is another advanced medical imaging diagnosis technology developed after X-ray CT scanning. This technology has the advantages of high resolution, multiple imaging parameters, arbitrary slices, and no ionizing radiation damage to the human body. The MRI signal intensity of human tissue mainly depends on the proton density N(H) and relaxation properties of the tissue (longitudinal relaxation time T 1 , the transverse relaxation time T 2 ), when the proton density of a specific tissue is constant, the length of the proton relaxation time determines the signal int...

Claims

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Application Information

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IPC IPC(8): A61K49/06
Inventor 裴奉奎李中峰李晓晶李伟生
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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