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Fructose-1,6-diphosphate calcium preparation and uses

A technology of diphosphoric acid and fructose diphosphate, applied in the field of fructose-1, can solve the problems of difficult absorption, poor absorption, large dosage, etc.

Active Publication Date: 2006-11-22
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Current research shows that many of the above calcium preparations still have some common disadvantages of poor absorption and large dosage.
Calcium supplementation focuses on absorption, but the calcium contained in plant foods and many calcium salt drugs are often not easily absorbed by the body

Method used

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  • Fructose-1,6-diphosphate calcium preparation and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Configure 58L of FDP solution (concentration: 86g / L), and adjust the pH to 5.0. Add 2L CaCl 2 Solution, molar concentration 7.2mol / L, stirred at 250rpm for 30min, concentrated in vacuum, slowly added 2 times the volume of the solution to obtain alcohol, stirred for 30min, vacuum filtered, washed with a small amount of 80% alcohol water, and then washed with anhydrous Alcohol dehydration twice, vacuum filtration, and spray drying to obtain 5.1 kg of fructose-1,6-diphosphate monocalcium salt with a purity of 99.0% and a yield of 95% of the theoretical value.

Embodiment 2

[0051] Configure 50L of FDP solution (concentration: 34.5g / L), and adjust the pH to 2.0. Add 5L Ca(NO 3 ) 2 (Concentration is 5.04mol / L), under the condition of 250rpm, stir and react for 4h, concentrate in vacuo, add twice the volume of ethanol, and stir for 15min, vacuum filter after fructose-1,6-diphosphate monocalcium salt crystallization , washed with a small amount of 80% alcohol water, then dehydrated twice with absolute alcohol, vacuum filtered, crystallized in 3 times alcohol, freeze-dried fructose-1,6-diphosphate monocalcium salt 1.76kg, purity 99.0 %, the yield is 96% of theoretical value.

Embodiment 3

[0053] Configure 5L of FDP solution (concentration is 92g / L), adjust the pH value to 6.0 and add 500ml CaCl 2 Solution (concentration is 2.7mol / L), stirred for 4h, added 2.5 volumes of acetone, and stirred for 15min, vacuum filtered after crystallization, washed with a small amount of 80% ethanol water, then dehydrated twice with absolute alcohol, vacuum After suction filtration, 501.1 g of fructose-1,6-diphosphate monocalcium salt was spray-dried, with a purity of 99.0% and a yield of 95% of the theoretical value.

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PUM

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Abstract

The invention discloses a making method and appliance of 1, 6-fructose biphosphate-calcium salt in the treatment or anti-osteoporosis or fracture drug, which is characterized by the following: making the molar rate of 1, 6-fructose biphosphate and solution of CaCl2 and Ca(NO3)2 at 1:1 with calcium salt density lower than 10 mol per L; controlling the reacting solution pH at 2.0-6.5; stirring; crystallizing; drying to produce 1, 6-fructose biphosphate-calcium salt as water-soluble calcium salt; improving the solubility and body intaking rate; providing metal ionic calcium of mother FDP as high-energy base material for tissue and cell needed energy through positive transmission; increasing the biological effect of calcium.

Description

technical field [0001] The invention relates to a chemical synthesis method and its application, in particular to the preparation and application of fructose-1,6-diphosphate monocalcium salt Background technique [0002] Calcium (Ca) is a constant element in the human body, containing 1200g in the human body, 99% of which is concentrated in bones and teeth, mainly in the form of hydroxyapatite, and the remaining 1% exists in the form of free or combined ions Soft tissue cells and blood. Normal plasma calcium concentration is 2.25-2.27mmol / L. The stability of blood calcium concentration plays a pivotal role in physiological processes such as nerve and muscle stress, transmission of nerve impulses, maintenance of cardiac rhythm, blood coagulation, and cell adhesion. There is a blood calcium homeostasis system in the human body, including a huge bone calcium pool and parathyroid hormone, calcitonin, and vitamin D involved in the regulation of bone calcium-blood calcium balanc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H11/04A61K31/7024A61P19/08A61P19/10
Inventor 应汉杰吕浩赵谷林
Owner NANJING UNIV OF TECH
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