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Medicine composition for treating cardiac and cerebral vascular diseases

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied in the field of pharmaceutical compositions whose active ingredients are medicinal active ingredients, and can solve problems such as difficulty in obtaining satisfactory curative effect of drugs, complex causes of disease, and numerous influencing factors

Inactive Publication Date: 2006-11-08
SICHUAN INST OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Cardiovascular and cerebrovascular diseases are diseases of a complex system with complex pathogenesis and numerous influencing factors. It is difficult to achieve satisfactory curative effect with drugs with a single active ingredient or single target
At present, traditional Chinese medicine compound drugs are mostly used in combination with medicinal materials. The volume and dosage of drug preparations are large, the active ingredients are not clear, and their absorption and bioavailability are not ideal, which affects the efficacy of drugs.
In addition, the unstable quality of medicinal materials can easily lead to unstable drug quality, which also makes the controllability of drug quality not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A single pure ligustilide was obtained by separation and purification of the volatile oil of Rhizoma Chuanxiong respectively, and the volatile oil of Acorus was obtained from the medicinal material of Acorus acorus by steam distillation. Take 2 g of ligustilide, 10 g of volatile oil of Acorus calamus (which contains 39.6% of β-asarone), add 120 g of soybean oil for injection, preheat to 55°C as the oil phase, and set aside. Take another 12g of soybean lecithin for injection, add 500ml of water for injection to disperse, then add 25g of glycerin for injection, stir to dissolve, heat to 55°C, and continue to stir, while slowly adding the oil phase, and homogenize at high speed for 6 minutes to prepare colostrum. Pass the colostrum through a high-pressure homogenizer for 4 cycles to obtain a submicron emulsion. Under low-speed stirring, add submicron emulsion and water for injection to 1000ml, filter, subpackage, and sterilize to obtain emulsion injection.

Embodiment 2

[0020] The volatile oil of Ligusticum chuanxiong was obtained from the medicinal material of Rhizoma Chuanxiong by steam distillation; the medicinal material of Shichangpu was obtained by supercritical CO 2 Extract the volatile oil of Shichangpu. Take 6g of Chuanxiong volatile oil (containing 35.1% of ligustilide) and 20g of Shichangpu volatile oil (including 53.1% of β-asarone), add them to the PEG-6000 melt, stir and mix, and make it in a dropping pill machine 5000 drop pills are the described pill form medicine.

Embodiment 3

[0022] Take 15g of ligustilide and 15g of volatile oil of Shichangpu, add 40g of soybean oil, and use it as the oil phase for later use. Take 3g of egg yolk lecithin, 12g of glycerin, 5g of tragacanth gum, 0.5g of ethylparaben and an appropriate amount of food flavor, add 250ml of distilled water, stir to dissolve, heat to 70°C, and continue to stir, while slowly adding the oil phase, high-speed Homogenize for 8 minutes to prepare colostrum, circulate the colostrum through a high-pressure milk homogenizer for 6 times, add distilled water to 500ml under low-speed stirring, filter, pack, put it in a special nasal drop bottle or a spray bottle, and get the nasal drop Sprays and sprays.

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PUM

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Abstract

The medicine composition for treating cardiac and cerebral vascular diseases has ligustilide and volatile grassleaved sweetflag rhizome oil in the weight ratio of 1 to 0.5-20 as effective medicinal components and contains also borneol and musk and pharmaceutically acceptable supplementary material. Test proves the synergistic effect between ligustilide and volatile grassleaved sweetflag rhizome oil as well as of borneol and musk in resisting cerebral ischemia reperfusion injury and resisting anoxia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, in particular to a pharmaceutical composition which uses active ingredients in natural medicines as medicinal active ingredients. Background technique [0002] Cardiovascular and cerebrovascular diseases are common and frequently-occurring diseases, especially among middle-aged and elderly people, which seriously endanger people's health and quality of life. Traditional single Chinese medicine and corresponding compound medicine have certain preventive and therapeutic effects on cardiovascular and cerebrovascular diseases. Such as Chuanxiong injection, the main active ingredient is Chuanxiong volatile oil, in which the content of ligustilide is the highest (Wang Shuqi, "Research on Chinese Patent Medicine", 1981, 10:31; Lai Fusheng et al., "Shanghai Medicine", 1995, 18(3): 157 ), clinical and animal experiments have proved that Chuanxiong in...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K9/08A61K9/12A61K31/045A61K31/365A61K35/55A61P7/02A61P9/10
Inventor 易进海陈燕刘云华刘玉红黄志芳
Owner SICHUAN INST OF CHINESE MATERIA MEDICA
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