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Externally applied compound gel and its preparing method

A technology of compound gel and hydrochloric acid is applied in the field of new pharmaceutical dosage forms to achieve the effects of being easy to receive, improving medication compliance, and being easy to spread and wash off.

Inactive Publication Date: 2006-11-08
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But there is still a lack of a kind of external compound condensate that can treat ringworm (tinea corporis, jock itch, tinea manuum and tinea capitis, etc.), skin yeast infection caused by Candida, and diseases such as onychomycosis caused by moldy fungi at present. glue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1. The preparation of compound gel for external use

[0022] Prescription: Terbinafine Hydrochloride 1.0g

[0023] Clobetasol Propionate 0.03g

[0024] Carbomer 941 0.5g

[0025] Hypromellose 10.0g

[0026] Triethanolamine 1.5g

[0027] Glycerin 15.0g

[0028] Propylene glycol 10.0g

[0029] Ethanol 10.0ml

[0030] Benzyl alcohol 0.5g

[0031] Add purified water to 100g

[0032] Preparation:

[0033] 1. Take carbomer, grind it with glycerin, add 10ml of purified water to fully swell the carbomer, and obtain the carbomer matrix;

[0034] 2. Take hydroxypropyl methylcellulose, add 15ml of 90°C water and stir quickly to obtain a uniform white hydroxypropyl methylcellulose solution, add it to the carbomer matrix and mix well for later use;

[0035] 3. Take terbinafine hydrochloride and clobetasol propionate, dissolve them in ethanol, and slowly add them to the carbomer matrix under stirring;

[0036...

Embodiment 2

[0039] Embodiment 2. The preparation of compound gel for external use

[0040] Prescription: Terbinafine Hydrochloride 1.0g

[0041] Clobetasol Propionate 0.03g

[0042] Carbomer 941 1.5g

[0043] Triethanolamine 2.5g

[0044] Glycerin 10.0g

[0045] Diethylene glycol 10.0g

[0046] Ethanol 10.0ml

[0047] Benzyl alcohol 0.5g

[0048] Distilled water up to 100g

[0049] Preparation:

[0050] 1. Take carbomer, add glycerin to grind and moisten it, add 20ml of distilled water to fully swell the carbomer, and obtain the carbomer matrix;

[0051] 2. Take terbinafine hydrochloride and clobetasol propionate, dissolve them in ethanol, and slowly add them to the carbomer matrix under stirring;

[0052] 3. Slowly add diethylene glycol to the mixture obtained in the previous step, and stir evenly;

[0053] 4. Add triethanolamine and benzyl alcohol dropwise to the mixture obtained in the previous step, then add distilled water to ...

Embodiment 3

[0055] Embodiment 3. Preparation of compound gel for external use

[0056] Prescription: Terbinafine Hydrochloride 1.0g

[0057] Clobetasol Propionate 0.05g

[0058]Carbomer 941 1.5g

[0059] Sodium bicarbonate 2.5g

[0060] Diethylene glycol 10.0g

[0061] Sorbitol 10.0g

[0062] Ethanol 10.0ml

[0063] Methylparaben 0.1g

[0064] Add purified water to 100g

[0065] Preparation:

[0066] 1. Take carbomer, add diethylene glycol to grind and moisten it, add 20ml of purified water to fully swell the carbomer, and obtain the carbomer matrix;

[0067] 2. Take terbinafine hydrochloride and clobetasol propionate, dissolve them in ethanol, and slowly add them to the carbomer matrix under stirring;

[0068] 3. Slowly add propylene glycol to the mixture obtained in the second step, and stir evenly;

[0069] 4. Add triethanolamine and methylparaben dropwise to the mixture obtained in the previous step, then add purified water to the fu...

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Abstract

The present invention relates to externally applied compound gel, and especially a kind of externally applied compound gel with Terbinafine Hydrochloride (TER-HCL) and Clobetasol Propionate (CBT) as main components and its preparation process. The externally applied compound gel is used in treating tinea, candida caused skin infection, mould caused tinea unguium, etc. The present invention has convenient use and high healing rate.

Description

technical field [0001] The invention relates to a new type of pharmaceutical dosage form, in particular to a treatment for ringworm (tinea corporis, jock itch, tinea manuum, tinea capitis, etc.), skin yeast infection caused by Candida, and onychomycosis caused by moldy fungus and other diseases Compound gel for external use and preparation method thereof. Background technique [0002] Terbinafine Hydrochloride (TER-HCL) has the effect of specifically inhibiting squalene cyclooxygenase. Fungal cells continuously ingest squalene, resulting in cell membrane damage and fungal cell death. This is its bactericidal effect. In addition, squalene epoxidase is the key enzyme for the formation of ergosterol. Since squalene cannot be epoxidized, the synthesis of ergosterol, the main component of the sensitive fungal cell membrane, is reduced, thereby inhibiting the activity of fungal cells. This is its Antibacterial effect. Therefore, the mechanism of action of terbinafine hydrochlori...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61K9/00A61K31/137A61P17/00A61P31/10
Inventor 高静高申储藏丁雪鹰管斐吕莹
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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