Use of fritillaria alkaloid extract in preparation of medicine for treating tumor

A technology of Fritillaria alkaloids and tumor drugs, which can be applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulas, etc., can solve the problems of limited practicality and effectiveness, and achieve the effect of great application value

Inactive Publication Date: 2006-11-01
SHANGHAI NOVANAT BIORESOURCES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Radiation therapy mainly destroys tumor cells through irreparable massive damage to DNA, but it also kills many normal cells at the same time, so the practicability and effectiveness of these treatments are very limited
There is no research report on the treatment of basal cell carcinoma with Fritillaria and its extracts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] Example 1, the application example of the fritillaria alkaloid extract preparation of the present invention:

[0024] A 68-year-old male patient suffered from a large area of ​​ulcerative basal cell carcinoma on the upper part of the nose. Treatment of lower half of basal cell carcinoma with fritillary alkaloid extract cream. Every three hours, directly apply about 20mu.l Fritillaria alkaloid extract cream to the lower half of the basal cell carcinoma affected area, while the upper half is not applied. After 54 hours of treatment, tumors were excised for observation. It can be clearly observed that in the upper part of the treatment with Fritillaria alkaloid extract cream, the tumor is rapidly inhibited, while the lower part has no obvious change. In addition, the resected tumors were marked with H&E. It can be seen that a large number of tumor cells died in the treated part, and cysts of various sizes were formed. In contrast, the untreated fraction was a firm tumor...

example 2

[0026] An 82-year-old male patient suffered from trichoepithelial tumor on the cheek. Apply 25mu.l Fritillaria alkaloid extract cream directly to the affected area every three hours. After 24 hours, the treatment was interrupted, and the skin at the tumor was excised for observation. It can be observed in the residual tumor cells that the cells start to die. In addition, the fetal mass near the affected area became smaller and less pigmented after 24 hours of treatment.

example 3

[0028] A 59-year-old man presented with nevus-like basal cell carcinoma of the lower eyelid. Except the marked place, all other nodules were treated with 20mu.l fritillary alkaloid extract cream every four hours. Marked nodules can only be treated by diffusion of the cream. On the third day after receiving the treatment, the tumor in the affected area was greatly reduced, and only a small visible part remained. The treatment was discontinued and follow-up observations were made, and no significant tumor suppression was observed. Treated tumor sites marked by H&E showed numerous cystic spaces free of tumor cells. After 6 days, the skin of the original tumor was excised for observation. Residual tumor cells, especially those near the cyst margin, displayed an unusually high frequency of cellular differentiation. However, no such phenomenon was observed in the excised biopsy. By observing the nodules labeled with Ber-Ep4 in immunohistochemistry, it was confirmed that the dif...

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PUM

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Abstract

An application of the fritillaria alkaloid extract in preparing medicines for treating tumor, especially the basal cell cancer, is disclosed.

Description

Technical field: [0001] The invention relates to plant extracts and applications thereof, especially the application of Fritillaria alkaloid extracts in the preparation of medicines for treating basal cell carcinoma (BCC) and other tumors. Background technique: [0002] Fritillary is the dry bulb of a variety of plants in the genus Fritillaria of the family Liliaceae. There are more than 60 species in the world, and 20 species in China. Except Guangdong, Guangxi, Fujian, Taiwan and other provinces, other provinces and regions are distributed. Among them, Xinjiang, Sichuan, Hubei, Anhui and other places are rich in varieties. As a commonly used traditional Chinese medicine, Fritillaria is often used for relieving cough and reducing phlegm, clearing away heat and dissipating stagnation. Studies in recent years have shown that Fritillaria has many biological activities, such as antibacterial, sedative and analgesic effects, anti-ulcer effects, anti-platelet aggregation effects...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61P35/00
Inventor 康露周剑侠范小兵沈征武
Owner SHANGHAI NOVANAT BIORESOURCES CO LTD
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