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Tissue engineering bone containing innervation and its construction

A tissue-engineered bone and nerve innervation technology, applied in the direction of bone/connective tissue cells, bone implants, medical science, etc., can solve the problem that no one is exploring, and achieve fast repair speed, good repair effect, and simple operation. Effect

Inactive Publication Date: 2006-11-01
NAN FANG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there have been many achievements in the promotion of bone vascularization in tissue engineering, but no one has explored the neuralization construction at home and abroad.

Method used

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  • Tissue engineering bone containing innervation and its construction
  • Tissue engineering bone containing innervation and its construction
  • Tissue engineering bone containing innervation and its construction

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Embodiment Construction

[0028] The tissue engineered bone containing innervation of the present invention, such as figure 1 As shown, it includes a carrier scaffold 1 and a seed cell 2. The seed cell 2 is attached to the carrier scaffold 1 to form a complex with a three-dimensional structure of bone tissue and biological activity. The carrier scaffold 1 is a biodegradable material containing innervation , the innervation is to implant the sensory nerve bundle 3 in the carrier bracket; the seed cells 2 are bone marrow stromal stem cells (BMSc), and the bone marrow stromal stem cells are taken from autologous bone marrow, separated and expanded to cell Density is 10 6 -10 7 pieces / ml.

[0029] Such as figure 2 As shown, the innervation is combined implantation of sensory nerve bundle 3 and motor nerve bundle 4 in carrier bracket 1 .

[0030] Such as image 3 and Figure 4 As shown, the tissue engineered bone complex is also implanted with a vascular bundle 5 .

[0031] The biodegradable materia...

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Abstract

A tissue-engineered bone containing innervation used for repairing dysostosis with high speed and effect has a carrier scaffold and the seed cells attached to said carrier scaffold to form a bioactive 3D bone tissue structure. Said carrier scaffold is a biodegradable material containing innervation. Said innervation is to implant the sensory nerve tracts into said carrier scaffold. Said seed cell is the stem cell of bone marrow matrix. Its configuring process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of constructing artificial organs by tissue engineering method in biomedical engineering, and relates to a tissue engineering bone with nerve innervation and a construction method thereof. Background technique [0002] In recent years, with the development of tissue engineering technology, reports on the research and development of biological substitutes capable of repairing, maintaining or improving damaged tissue functions have increased year by year, and there are quite a few research reports on tissue engineered bone. At present, the research, development and utilization of tissue engineered bone has become a hot spot in the repair and treatment of large segmental bone defects. [0003] Most of the tissue-engineered bone currently researched and developed is to use seed cells and biodegradable material composites to implant the bone defect in the body to repair and reconstruct the missing bone tissue. So...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61B17/56A61L27/00C12N5/0775
Inventor 裴国献张元平王永刚金丹魏宽海秦煜黄爱文胡稷杰
Owner NAN FANG HOSPITAL
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