Method for preparing medical filler with non-crystal oxide ion-slow-release surface
A technology of amorphous oxides and implant materials, which is applied in the field of preparation of medical biomaterials, can solve the problems of high solubility, insufficient interaction ability, and insufficient activity, and achieves simple process, promotion of adsorption, and promotion of mineralization. Effect
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example 1
[0019] Part of the OH group formed by dissolving phosphorus pentoxide in ethanol is replaced by an alcohol group, with a molecular formula such as PO(OH) X (OEt) 3-X The phosphoric acid with a concentration of 1 mol / L was mixed with the phosphoric acid hexafluorophosphoric acid in a molar ratio of F:P=0.15:1 in an ice-water bath environment. Calcium nitrate was dissolved in the above mixed solution with a molar ratio of Ca:P=0.8:1, and heated to reflux for 24 hours. The zinc nitrate is dissolved in the refluxed mixed solution according to the proportion of trace elements accounting for 0.01% of the mass of the solute to form a sol. After immersing the Ti6A14V substrate in the sol for 5 hours, slowly pull it out of the liquid surface at a speed of 0.5 cm / min by dipping and pulling method, dry it at 150°C, and heat-treat it at 500°C for 15 minutes to obtain A medical implant material with an ion slow-release surface layer.
example 2
[0021] Dissolve triethyl phosphite in ethanol to form a 2 mol / L solution, and mix this solution with trifluoroacetic acid at a molar ratio F:P=0.15:1 in an ice-water bath environment. Calcium nitrate was dissolved in the above mixed solution with a molar ratio of Ca:P=1:1, and heated to reflux for 24 hours. The zinc nitrate is dissolved in the refluxed mixed solution according to the proportion of trace elements accounting for 0.04% of the mass of the solute to form a sol. After immersing the pure titanium substrate in the miscible glue for 8 hours, slowly pull it out of the liquid surface at a speed of 0.5 cm / min by dipping and pulling method, after drying at 180°C, heat treatment at 400°C for 4 hours, A medical implant material with zinc ion sustained release surface layer is obtained.
example 3
[0023] Part of the OH group formed by dissolving phosphorus pentoxide in ethanol is replaced by an alcohol group, with a molecular formula such as PO(OH) X (OEt) 3-X Phosphoric acid with a concentration of 1 mol / L, the solution was mixed with ammonium hexafluorophosphate in a molar ratio of F:P=0.12:1 in an ice-water bath environment. Calcium nitrate was dissolved in the above mixed solution with a molar ratio of Ca:P=0.9:1, and heated to reflux for 24 hours. The zinc nitrate is dissolved in the refluxed mixed solution to form a sol according to the proportion that the trace element is 0.03% of the mass of the solute. After immersing the Ti6Al4V substrate in the mixed solution for 10 hours, slowly pull it out of the liquid surface at a speed of 0.4 cm / min by dipping and pulling method, preheat at 200°C for 20 minutes, and heat treat at 450°C for 2 hours to obtain The amorphous oxide surface layer with zinc slow release function.
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