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Pharmaceutical composition containing caffeoylquinic acids

A technology of caffeoylquinic acid and composition, applied in the field of functional health care products or cosmetics, medicine, composition containing natural plant extracts or monomers, can solve the problem that no scientific basis is provided, no hint or try and other questions

Active Publication Date: 2006-10-04
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, the existing technology has not provided scientific basis for the basic issues of whether mono / dicaffeoylquinic acid can be used in combination with peony, and whether the mechanism of action of the two is additive, synergistic or antagonistic.
As for whether the two can be used in combination for other diseases (such as brain cell protection, Alzheimer's disease), there is no similar suggestion or attempt in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0196] Example 1 Capsules

[0197] Take 5g of red peony, crush it into coarse powder, add 75% ethanol and reflux for extraction three times, the first and second times each for 2 hours, the third time for 1 hour, combine the extracts, concentrate under reduced pressure to about 400ml, and extract three times with n-butanol , 300ml each time, combine the n-butanol extracts, concentrate under reduced pressure until there is no n-butanol taste, add 200ml of water, heat to dissolve, filter, and spray dry the filtrate to obtain extract I for use;

[0198] Take one part of extract I, take 1 g of honeysuckle extract (with a content of chlorogenic acid not less than 50%), add starch and magnesium stearate, mix them, and put them into hard capsules. After testing, each capsule contains 500 mg of chlorogenic acid and 100 mg of paeoniflorin.

Embodiment 2

[0199] Example 2 Tablets

[0200]Take 5 kg of coffee beans and extract with 95% ethanol. The extract is dissolved in water and extracted with petroleum ether, ethyl acetate and n-butanol to obtain petroleum ether, ethyl acetate and n-butanol. The ethyl acetate fraction was subjected to silica gel column chromatography and MCI column chromatography to obtain 8 g of dicaffeoyloxyquinic acid and 4 g of quinic acid, respectively. Then, 100 mg of dicaffeoyloxy-quinic acid was dissolved in 1000 ml of water to prepare a 0.1% concentration aqueous solution for heating and dissolution, and after mixing evenly, it was put into a medicine bottle and sealed, sterilized to make a product, and extract II was obtained for later use.

[0201] Take two parts of extract I and one part of extract II of Example 1, add low-substituted hydroxypropyl cellulose, magnesium stearate, starch, and microcrystalline cellulose, and granulate according to standard granulation and tableting processes. After testi...

Embodiment 3

[0202] Example 3 Soft capsules

[0203] Take a half part of extract I and five parts of extract II of Example 1, add starch and magnesium stearate, mix well, and prepare soft capsules according to standard techniques. After testing, each capsule contains 500mg of dicaffeoylquinic acid and 50mg of paeoniflorin.

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PUM

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Abstract

The invention relates to a medicinal functional compound for health products or cosmetics, its preparing process and use thereof, wherein the compound comprises natural plants extract or monomer as the active constituents. The pharmaceutical composition can be used for treating and / or preventing diabetes and complications, cardiovascular and cerebrovascular diseases, senile dementia and hyperlipemia.

Description

Technical field [0001] The invention relates to a combination for medicinal, functional health care products or cosmetics, specifically, a composition containing natural plant extracts or monomers and its application in medicines, functional health care products or cosmetics. Background technique [0002] With the rapid development of modern science, people pay more and more attention to "natural" medicines. In recent years, the medical field has done a lot of work in the treatment of cardiovascular and cerebrovascular diseases, lowering blood sugar and other medicinal plants, and strengthened the analysis and research of biologically active substances in order to further clarify their efficacy. However, the results achieved are limited. This is mainly due to the complicated pathogenesis of cardiovascular and cerebrovascular diseases and diabetes, which are often accompanied by one or more complications of different types. The existing single natural active ingredient is difficul...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K31/7048A61K36/894A61K36/744A61K36/65A61K36/46A61K36/35A61K36/28A61K36/18A61K8/97A61P3/10A61P3/06A61P9/00A61P25/28A61Q19/00
Inventor 林艳和
Owner YUNNAN BIOVALLEY PHARMA CO LTD
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