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Process for the production of heparin sodium crude

A production method and heparin sodium technology are applied in the field of heparin sodium crude product production, can solve the problems of low yield, high discharge concentration of waste liquid, pollution, etc., and achieve the effect of high yield

Inactive Publication Date: 2006-09-27
孙剑鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This traditional process has the defects of low harvest rate, unstable harvest, large loss, high concentration of waste liquid discharge and serious pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] (1) Dissociation: the small intestinal mucosal fluid (solid-liquid ratio is about 1:9) is pumped into the reaction tank (pool), adjust the pH value to 9.5-10.5 with caustic soda, add 3-5% (weight ratio) of Nacl, Add enzyme per 10g / 100 roots, heat up to 56-81°C, stop heating, keep the temperature for 1-3 hours, heat up to 83-98°C, add complexing agent alum, and add buffer solution disodium EDTA, stir for 1- Make it separate and precipitate for 3 minutes, then use physical (mechanical compression) or chemical method (adding water purifier alum or calcium carbonate or polyaluminum chloride) to collect the solid, and the clear liquid is pumped into another container;

[0013] (2) Concentration: Concentrate the heparin in the clear liquid with a microfiltration membrane concentrator or distillation or resin, and collect it to one-twentieth volume of the original clear liquid;

[0014] (3) Dehydration and drying: add 85-90% ethanol to the concentrated solution until the alcoh...

Embodiment 2

[0016] (1) Dissociation: pump the small intestinal mucosal fluid (solid-liquid ratio is about 1:9) into the reaction tank (pool), adjust the pH value to 9.5-10.5 with caustic soda, add 3-5% (weight ratio) of NaCl , add enzyme per 10g / 100 roots, raise the temperature to 56-81°C, stop heating, keep the temperature constant for 1-3 hours, raise the temperature to 83-98°C, add complexing agent calcium carbonate powder, and add buffer anhydrous sodium sulfate , stir for 1-3 minutes to make it produce separation and precipitation, then use physical (mechanical compression) or chemical methods (adding water purifying agent alum or calcium carbonate or polyaluminum chloride) to collect the solid, and the clear liquid is pumped into another container;

[0017] (2) Concentration: Concentrate the heparin in the clear liquid with a microfiltration membrane concentrator or distillation or resin, and collect it to one-twentieth volume of the original clear liquid;

[0018] (3) Dehydration a...

Embodiment 3

[0020] (1) Dissociation: pump the small intestinal mucosal fluid (solid-liquid ratio is about 1:9) into the reaction tank (pool), adjust the pH value to 9.5-10.5 with sodium carbonate, and add 3-5% (weight ratio) of NaCl , add enzyme per 10g / 100 roots, heat up to 56-81°C, stop heating, keep the temperature for 1-3 hours, heat up to 83-98°C, add complexing agent polyaluminum chloride, and add buffer sodium bicarbonate , stir for 1-3 minutes to make it produce separation and precipitation, then use physical (mechanical compression) or chemical methods (adding water purifying agent alum or calcium carbonate or polyaluminum chloride) to collect the solid, and the clear liquid is pumped into another container;

[0021] (2) Concentration: Concentrate the heparin in the clear liquid with a microfiltration membrane concentrator or distillation or resin, and collect it to one-twentieth volume of the original clear liquid;

[0022] (3) Dehydration and drying: add 85-90% ethanol to the c...

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PUM

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Abstract

The invention discloses a liquemin bullion producing method, which comprises the following steps: extracting small intestine mucosa liquid in the reactor tank; using industrial alkali to adjust pH value between 9.5 and 10.5; adding 3-5 percent NaCl; putting enzyme 10 g per 100 bars; heating until 56-81 deg.c; stirring 1-3 min to produce sediment; collecting solidity through physical or chemical method; condensing the supernatant disebrin through micro-filter membrane condenser or resin; collecting one twentieth bulk to primary supernatant; dehydrating; drying; adding 85-90 alcohol in the condensed liquid to 40-50 degree; drying the sediment to produce liquemin bullion.

Description

Technical field: [0001] The invention relates to a method for isolating existing compounds from small intestines of animals, in particular to a method for producing crude heparin sodium. Background technique: [0002] As we all know, the extraction of heparin sodium is generally carried out by scraping the small intestine of animals (especially pigs). Then, after alcohol precipitation and dehydration, the resultant is dried. This traditional process has the defects of low harvest rate, unstable harvest, large loss, high concentration of waste liquid discharge and serious pollution. Invention content: [0003] The object of the present invention is to provide a kind of heparin sodium crude product production method that yield is high, waste liquid discharge is pollution-free and can recycle in order to overcome the deficiencies in the prior art. Its specific production method is: [0004] (1) Dissociation: pump the small intestinal mucosal fluid (solid-liquid ratio is ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/10
Inventor 孙剑鸣
Owner 孙剑鸣
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