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Use of alpha-ketoglutaric acid for the treatment of malnutrition or high plasma glucose condition

A technology for glucose and symptoms, applied in the field of improving the absorption of amino acids, can solve problems such as incomplete understanding of the mechanism of action

Inactive Publication Date: 2006-08-23
ESSENTYS AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its mechanism of action is not fully understood (Pierzynowski, S.G., and Sjodin, A. (1998) J. Anim. a. Feed Sci. 7:79-91; and Pierzynowski S.G., et al. Eds: KBK Knutsen and J-E Lindberg. , Uppsala 19-21 June, 2001)

Method used

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  • Use of alpha-ketoglutaric acid for the treatment of malnutrition or high plasma glucose condition
  • Use of alpha-ketoglutaric acid for the treatment of malnutrition or high plasma glucose condition

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0230] Example 1 - Measurement of plasma AKG, glucose, ammonia, blood flow and overall urea flow.

[0231] Purpose

[0232] The purpose of this example was to evaluate the effect of AKG infusion on plasma AKG, glucose, ammonia, blood flow and overall urea flow.

[0233] Animal experiment

[0234] Piglets were deprived of food for 15 hours before starting the experiment.

[0235] On the day of the experiment, at -1 hour, continuous duodenal infusion of a pre-prepared formula [Litter Life, Merrick, Middleton, WI; 7.75 mL / (kg h)] (7.75 mL / kg; 25% wt / wt water solution; oral administration), which is prepared as a 25% (wt / wt) water solution, it can provide about 920kJ and 12.5g protein / (kg d).

[0236] Saline (control; 930 mmol / L NaCl) or sodium-AKG (Na-AKG), 930 mmol / L, purchased from Sigma-Aldrich, St. Louis, MO) was dissolved in the formula.

[0237] Based on previous data (6), the AKG content was selected by an outside laboratory where, in order to observe a detectable AKG...

example 3

[0276] Example 3 - Comparison of the effects of enterally administered Na-AKG and chitosan-AKG on the absorption of amino acids and ketoacids into enterocytes and plasma, and their metabolism

[0277] Purpose

[0278] The purpose of this example was to compare the effects of enterally administered Na-AKG (or Na salt of AKG) and chitosan-AKG on the absorption of amino acids and ketoacids into enterocytes and plasma and their metabolism. In addition, the effects of Na-AKG and chitosan-AKG on the conversion of ketoacids to amino acids were determined by monitoring blood plasma amino acid content. This study tested the hypothesis that AKG affects the intestinal conversion of ketoacids to amino acids and improves protein synthesis.

[0279] Animal experiment

[0280] A total of three pigs were used in this experiment. These pigs weighed approximately 20kg. The pigs were housed separately in boxes and fed a standard diet for 4-5 days to allow acclimatization to the new facility....

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PUM

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Abstract

A method for improving adsorption of amino acids in a vertebrate, including mammal and bird, is included. The method comprises administering to a vertebrate, including mammal and bird, in a sufficient amount and / or at a sufficient rate to enable desire effect. AKG, AKG derivatives or metabolites, AKG analogues or mixture thereof. Also conteplated is a method for decreasing adsorption of glucose in a vertebrate, including mammal and bird, in the need thereof, AKG, AKG derivates or metabolites, AKG analogues or mixture thereof, for decreasing glucose adsorption as well as compositions for use in treatment.

Description

technical field [0001] The present invention relates to methods for improving the absorption of amino acids in vertebrates, including mammals and birds, and methods for reducing glucose absorption. The invention also relates to the production of compositions for improving the absorption of amino acids in said vertebrates. Background of the invention [0002] Diabetes mellitus is a serious metabolic disease defined by the appearance of chronically elevated plasma glucose levels. Typical symptoms of diabetes in adults are polyuria, polydipsia, ketonuria, rapid weight loss, and higher levels of plasma glucose. [0003] Normal fasting plasma glucose concentration is less than 115 mg / dl per liter. In diabetic patients, fasting concentrations above 140 mg per liter were found. Typically, diabetes arises due to damage to the beta cells of the pancreas. This damage can occur due to primary diabetes, in which beta cells are destroyed by the autoimmune system, or as a secondary di...

Claims

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Application Information

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IPC IPC(8): A61K31/198A23L1/305A61K
CPCA61K31/19A61K31/722A61K31/198A61K31/401A23L1/3051A23L33/175
Inventor S·G·皮尔茨诺夫斯基D·布林
Owner ESSENTYS AB
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