Medicine composition for treating hyperplasia of mammary glands and preparing technology
A technology for breast hyperplasia and composition, which is applied in drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., can solve problems such as unpleasantness and easy recurrence of patients, and achieves reduction of adverse reactions, slow dissolution and effect. lasting effect
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experiment example 1
[0054] Experimental example 1 Process technical conditions optimization
[0055] 1. On the basis of the original preparation process, investigate the amount of water added:
[0056] According to the production process of Hongjin Xiaojie Concentrated Pills, take one-eighth of the prescription amount of medicinal materials, grind them into coarse powder, add 6, 8, 10, and 12 times the amount of water to decoct three times, the first time for 2 hours, the second time The second time was 1.5 hours, and the third time was 1 hour. The decoction was combined, filtered, and concentrated to a dry paste. The yield of the paste and the extraction rate of n-butanol were investigated. The results are shown in Table 1:
[0057] Amount of water added (times)
Paste output (g)
Paste yield (%)
Butanol extraction rate (%)
6
8
10
12
40.60g
42.35g
44.10g
44.80g
11.6
12.1
12.6
12.8
1.423
1.515
1.555
1.5...
experiment example 2
[0066] Experimental example 2 Pilot test data
[0067] The three batches of pilot test data adopt the optimized process, and the three batches of samples are produced in the pilot test with 10 times the amount of the prescription. The obtained data are shown in Table 2:
[0068] batch number
experiment example 3
[0069] Experimental example 3 Pilot product inspection
[0070] Three batches of pilot products are inspected by "Chinese Pharmacopoeia" 2000 edition one pill item (appendix IA) requirement, and the results are shown in Table 3:
[0071] batch number
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