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Bendazac lysine eye drops with reduced irritability, its preparation method and application

A technology of benidalysine and eye drops, applied in the field of benidalysine eye drops and preparation, can solve problems such as affecting the confidence of patients to continue taking medication, and achieve the effect of improving irritation

Inactive Publication Date: 2006-04-26
浙江平湖莎普爱思制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because the drug has a transient burning adverse reaction in clinical use, resulting in pain and tearing, especially for newly diagnosed patients, this often affects the patient's confidence in continuing to use the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Bendazyl-lysine eye drops capable of reducing irritation, a medicament made of the following components and content percentage ratios

[0051] (Added L-lysine to the original prescription):

[0052] Bendazine 0.5%

[0053] Hypromellose 0.135%

[0054] Sodium dihydrogen phosphate.2H 2 O 0.0185%

[0055] Disodium hydrogen phosphate.12H 2 O 0.233%

[0056] Sodium chloride 0.81%

[0057] Sodium Thimerosal 0.001%

[0058] L-Lysine 0.25%

[0059] Add water for injection to 1000ml

[0060] Makes 1000ml

[0061] preparation:

[0062] 1. Take the prescribed amount of hypromellose, soak it with fresh water for injection (2 / 4 of the total amount) overnight, stir and heat to boil, keep it warm for 30 minutes, cool to room temperature, filter to obtain liquid A;

[0063] 2. Take the prescribed amount of sodium chloride, add fresh water for injection (1 / 4 of the full amount), stir and heat to 90°C, keep warm for 30 minutes, then add the prescribed amount of benzyl lysine...

Embodiment 2

[0067] Example 2 Bendax lysine eye drops for reducing irritation, a medicament made of the following components and content percentage ratios:

[0068] Bendalysine 0.25%

[0069] Sodium hyaluronate or 0.1%

[0070] [Polyethylene glycol] 0.1%

[0071] Sodium chloride 0.74%

[0072] Chlorobutanol 0.25%

[0073] L-Lysine 2.0%

[0074] add water for injection

[0075] Makes 1000ml

[0076] preparation:

[0077] 1. Take the prescribed amount of sodium hyaluronate or [polyethylene glycol], soak in fresh water for injection (2 / 4 of the total amount) overnight, stir and heat to 90°C for 30 minutes, cool to room temperature, filter to obtain liquid A ;

[0078] 2. Take the prescribed amount of sodium chloride, add fresh water for injection (1 / 4 of the total amount), stir and boil, keep warm for 30 minutes, then add the prescribed amount of benzyl lysine, stir evenly, and obtain liquid B;

[0079] 3. Dissolve the prescribed amount of chlorobutanol and L-lysine in 100ml of fre...

Embodiment 3

[0082] Example 3 Bendax lysine eye drops for reducing irritation, a medicament made of the following components and content percentage ratios:

[0083] Bendazine 0.5%

[0084] Methylcellulose or 0.2%

[0085] [β Cyclodextrin] 0.1%

[0086] Potassium chloride 0.74%

[0087] Methylparaben and Propylparaben 0.023%+0.011%

[0088] Glycerin 10ml

[0089] add water for injection

[0090] Makes 1000ml

[0091] preparation:

[0092] 1. Take the methylcellulose or [β-cyclodextrin] in the prescribed amount, soak one of the above thickeners with fresh water for injection (2 / 4 of the total amount) respectively overnight, stir and boil for 30 minutes, cool to room temperature, filtered to obtain liquid A;

[0093] 2. Take the prescribed amount of potassium chloride, add fresh water for injection (1 / 4 of the full amount), stir and boil, keep warm for 30 minutes, add the prescribed amount of benzyl lysine, and stir well to obtain liquid B;

[0094] 3. Dissolve the prescribed amoun...

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PUM

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Abstract

The invention discloses a bendazac lysine eye drops with reduced irritability, its preparation method and application, wherein the eye drop is prepared from bendazac lysine, thickening agent, buffering agent, preservative agent, isotonic agent, substance for reducing eye drop pungency and water for injection.

Description

1. Technical field [0001] The invention relates to medicines for eye drops, in particular to benda lysine eye drops (Shapuaisi) and its preparation method and application. The eye drops have the characteristics of reducing irritation. 2. Background technology [0002] The trade name of Sharp Aisi 0.5% Bendazac Lysine (Bendazac Lysine, BDL) eye drops is an aldose reductase inhibitor and is a new generation of anti-cataract drugs. It is mainly used to treat early senile cataracts. (Bendazac Lysine, BDL) is the only AR inhibitor that has been marketed abroad for the treatment of cataract. After extensive animal experiments and clinical studies in foreign countries, BDL was first listed in Italy (1983) by Anglini Pharmaceutical Group as an effective drug for treating cataract, and then registered in more than 20 countries in the world. It was published in USAN in 1988. After extensive animal experiments and clinical studies abroad, there are two kinds of 0.5g tablet and 0.5% ey...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/415A61P27/02
Inventor 张银娣陈德康吴建伟金弟沈建平丁虹彬金叶
Owner 浙江平湖莎普爱思制药有限公司
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