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Flavargine effervescent tablet

A technology of effervescent tablets and silver yellow, which is applied in the direction of drug delivery, plant raw materials, pill delivery, etc., and can solve the problems of increasing costs, limiting the application of effervescent agents of traditional Chinese medicine, production, transportation, carrying, and inconvenient use

Inactive Publication Date: 2006-03-08
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When traditional Chinese medicine is made into an effervescent dosage form, water extraction and alcohol extraction are usually used to obtain a variety of mixed macromolecular effective substances, including pectin, sugars, polysaccharides and other viscous substances. The disintegration is affected by viscous substances, and the disintegration is slow. On the other hand, in order to ensure the curative effect, the single-tablet Chinese medicine effervescent dosage form is taken in a large amount, which also affects the disintegration speed. In order to ensure disintegration, the excipients have to be increased The dosage makes some effervescent tablets need to be 4-5g / tablet, which not only increases the cost, but also brings inconvenience to production, transportation, carrying and use
The disintegration speed of traditional Chinese medicine effervescent preparations is as long as several minutes, and the advantages are not prominent compared with traditional Chinese medicine granules, which limits the application of traditional Chinese medicine effervescent preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1. Preparation of silvery yellow extract: Take honeysuckle, add water and decoct twice, each time for 2 hours, combine the decoction, filter, add lime milk to the filtrate to adjust the pH value to 10-12, let it stand, filter to collect the precipitate, Add an appropriate amount of water, add sulfuric acid to adjust the pH value to 6-7, stir well, filter, concentrate the filtrate to a thick paste, and dry to obtain the honeysuckle extract. Take Scutellaria baicalensis, add it to boiling water and decoct twice, each time for 1 hour, combine the decoction, filter, add sulfuric acid to the filtrate to adjust the pH value to 2, let it stand, filter the precipitate, wash with ethanol, dry, and obtain Scutellaria baicalensis extract. According to the ratio of 100 parts of honeysuckle extract: 40 parts of Scutellaria baicalensis extract, the silver yellow slice extract is obtained.

[0052] 2, prepare silver yellow effervescent solid tablet (100 pieces)

[0053] Formula rati...

Embodiment 2

[0062] 1, the preparation of silver yellow extract: with embodiment 1.

[0063] 2. Silver-yellow ring-shaped effervescent tablets (100 tablets)

[0064] Formula ratio:

[0065] Silver Yellow Extract 105g Tartaric Acid 140g

[0066] Cyclamate 5g Flavor 2g

[0067] Sodium bicarbonate 80g PEG 4000 5g

[0068] Microcrystalline Cellulose 30g PVP 33g

[0069] 3. Preparation method

[0070] The silver yellow extract obtained by drying is sealed and stored for later use; the tartaric acid, sodium bicarbonate, and microcrystalline cellulose are respectively pulverized through a 100-mesh sieve, and sealed and stored for later use; cyclamate and essence are pulverized through a 100-mesh sieve, and PEG 4000 is pulverized through a 140-mesh sieve Sieve; during the preparation process, control the ambient temperature of the preparation at 25°C and the humidity below 45%; mix the silvery yellow extract and tartaric acid evenly according to the required proportion, then add cyclamate and...

Embodiment 3

[0073] 1, the preparation of silver yellow extract: with embodiment 1.

[0074] 2, prepare silver-yellow ring-shaped effervescent tablets (100 tablets)

[0075] Formula ratio:

[0076] Silver Yellow Extract 67g Malic Acid 38g Citric Acid 120g

[0077] Aspartame 5g Acesulfame K 3g Flavor 2g

[0078] Sodium bicarbonate 30g Potassium carbonate 90g

[0079] Cross-linked polyvinylpyrrolidone 35g Magnesium stearate 10g

[0080] 3. Preparation method

[0081] The silver yellow extract obtained by drying is sealed and stored for later use; malic acid, citric acid, sodium bicarbonate, potassium carbonate, and cross-linked polyvinylpyrrolidone are respectively crushed through a 100-mesh sieve, and sealed and stored for later use; acesulfame potassium and essence are crushed through 100 mesh Mesh sieve, magnesium stearate is crushed through a 140 mesh sieve; during the preparation process, the ambient temperature of the preparation is controlled at 25°C and the humidity is below 45%...

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Abstract

The present invention relates to a ring-shaped yinhuang effervescent tablet for effectively curing acute and chronic tonsillitis, acute and chronic laryngopharyngitis and upper respiratory tract infection. It is made up by using Chinese medicinal material lonicera flower and scutellaria root as raw material.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine effervescent tablets, in particular to Yinhuang effervescent tablets. Background technique [0002] At present, the main effervescent tablets in my country are health care products, such as vitamin C, calcium supplement effervescent tablets, and effervescent tablets for gynecological external use, such as Jieeryin effervescent tablets, metronidazole vaginal effervescent tablets, etc. But oral Chinese medicine effervescent preparations are less. And make the effervescent tablet of oral pure Chinese medicine preparation with silvery yellow formula, rarely see report. In addition, annular tablets have been used in the food industry for a long time, but they are rarely used in the field of medicine, especially in the field of effervescent tablet preparation, and there are few reports. [0003] Traditional Chinese medicine effervescent tablet is a new dosage form, which has the advanta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61K36/539A61K9/20A61K9/46A61P11/04A61P11/00
Inventor 罗晓健杨世林王跃生饶毅魏惠珍王金钱张爱玲
Owner JIANGXI HERBFINE HI TECH
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