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Medicine composition for preventing and treating orthopedic diseases

A technology for orthopedic diseases and compositions, applied in the field of pharmaceutical compositions composed of elderberry extract and drynaria extract, can solve the problems of increasing the amount of ALP and not finding a large amount of osteoclast formation

Inactive Publication Date: 2006-03-08
孙毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Osteocyte culture and bioassay showed that drynaria can significantly increase the amount of ALP in the cells, and at the same time the ACP and PGE2 in the medium increased significantly, making the formation of multinucleated osteoclasts more active, but no huge amount of osteoclasts was found, which has a significant effect on the formation of osteoclasts. Osteocytes may act by modulating osteoclast activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1: Capsule prescription and process

[0067] Prescription (calculated as 1000 tablets)

[0068] Elderberry extract 20g

[0069] Drynaria fortunei extract 20g

[0070] Starch 150ml

[0071] Micronized silica gel 10g

[0072] Made into 1000 tablets

[0073] Take 25kg of dry stems and branches of elderberry, and extract 4 times with 95% ethanol under heating and refluxing. The extract is concentrated to obtain an extract, mixed with diatomaceous earth, and then extracted with petroleum ether, chloroform, methanol and water by percolation. The petroleum ether is separated repeatedly by silica gel low pressure column chromatography to obtain the elderberry extract.

[0074] Take Drynaria fortunei medicinal material, dry for 8 hours at 60°C, pulverize into coarse powder (24 mesh), weigh 1kg, add 10L of 60% ethanol, reflux for 1 hour, filter, add 10L of 60% ethanol, and reflux for 1 hour. The filtrates were combined, distilled under reduced pressure to remove alcohol, f...

Embodiment 2

[0076] Example 2: Powder injection prescription and process

[0077] Prescription (calculated by 1000 bottles)

[0078] Elderberry extract 10g

[0079] Drynaria fortunei extract 5g

[0080] Mannitol 250g

[0081] Water for injection 10g

[0082] 1000 bottles

[0083] The extraction method is the same as above. The molding process is as follows: take the prescription amount of elderberry extract, drynaria fortunei extract, mannitol, polyethylene glycol 400, 80% of the prescription amount to dissolve in water for injection; after initial filtration, use 0.2um microporous membrane for fine filtration; make up Water for injection to full volume; sub-package; freeze-dry; packaging.

example 3

[0084] Example 3: Injection prescription and technology

[0085] Prescription (calculated by 1000 bottles)

[0086] Elderberry extract 10g

[0087] Drynaria fortunei extract 5g

[0088] Water for Injection Add to 2000ml

[0089] 1000 bottles

[0090]The extraction method is the same as above. The molding process is as follows: take the prescription amount of elderberry extract, drynaria fortunei extract, and 50% of the prescription amount to dissolve in water for injection; after initial filtration of activated carbon, fine filtration with 0.2um microporous membrane; make up the water for injection to the full amount; determine the content; Distributed packaging; sterilization; light inspection; packaging.

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PUM

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Abstract

The present invention provides a Chinese medicine composite for effectively preventing and curing osteopathies with obvious therapeutic effect. It is made up by using extract of asiatic elder twig and extract of drynaria root.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating orthopedic diseases, in particular to a pharmaceutical composition composed of an elderberry extract and an Drynaria fortunei extract. Background technique [0002] Orthopedic disease is a worldwide health problem that has attracted more and more attention. For example, about 200 million people worldwide suffer from osteoporosis, and its incidence has jumped to the seventh place among common and frequently-occurring diseases. The latest research shows that osteoporosis, which has been regarded as a unique disease of the elderly in our country, actually exists in childhood. With the aging of the population becoming more and more obvious, osteoporosis and its complications, a degenerative disease that occurs frequently in middle-aged and elderly people, has become a social health problem that has attracted the attention of geriatricians and has attracted the attention of the soc...

Claims

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Application Information

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IPC IPC(8): A61K36/35A61K36/185A61K9/00A61P19/08A61P19/10
Inventor 孙毅
Owner 孙毅
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