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Injection with omeprazole and domperidone

A technology of domperidone and omeprazole, which is applied in the field of combined preparations of omeprazole and domperidone, and in the field of injections, can solve the problems of injection formulations without high bioavailability, etc., and achieve the effects of enhancing gastric motility, taking a long time, and relieving stomach pain Effect

Inactive Publication Date: 2006-02-22
张志生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] So far, the combination preparation of omeprazole and domperidone has not been seen in the prior art to jointly treat gastrointestinal diseases such as gastric ulcer, duodenal ulcer, gastroesophageal reflux disease, and functional dyspepsia. Highly bioavailable injectable dosage form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Prepare the freeze-dried powder injection of omeprazole sodium and domperidone according to the following formula:

[0035] Omeprazole sodium (equivalent to omeprazole 20g) 21.35g

[0036] Domperidone 10g

[0037] Mannitol 40g

[0038] Sodium edetate 0.75g

[0039] Appropriate amount of sodium hydroxide

[0040] The preparation method is as follows: Weigh the prescribed amount of omeprazole sodium, domperidone, mannitol and sodium edetate, dissolve them in an appropriate amount of water for injection, control the temperature at about 70°C and stir to dissolve; add 0.1mol / L sodium hydroxide solution, adjust the pH value to about 11.5, then add 0.1% (W / V) activated carbon, keep warm for 20 minutes, coarse filter and decarbonize, add water for injection to the full amount, mix well, measure the content and pH value , after passing the test, filter with a 0.22μm microporous membrane, fill in a 100-level environment with half-stoppering, freeze-dry in a freeze-drying bo...

Embodiment 2

[0042] Prepare the freeze-dried powder injection of omeprazole sodium and domperidone according to the following formula:

[0043] Omeprazole Potassium 15g

[0044] Domperidone 4g

[0045] Glucose 35g

[0046] EDTA 0.3g

[0047] Appropriate amount of sodium hydroxide

[0048] The preparation method is as follows: Weigh the prescribed amount of omeprazole potassium, domperidone, glucose and sodium edetate, dissolve it in an appropriate amount of water for injection, control the temperature at about 70°C and stir to dissolve it; add 0.1mol / 1 L of sodium hydroxide solution, adjust the pH value to be about 11.5, then add 0.1% (W / V) activated carbon, keep warm for 20 minutes, coarse filter and decarbonize, add water for injection to the full amount, mix, measure the content and pH value, After passing the test, filter it with a 0.22 μm microporous membrane, fill it with a half-stopper in an environment of 100 grades, put it in a freeze-drying box, freeze-dry it, press the stop...

Embodiment 3

[0050] Prepare the freeze-dried powder injection of omeprazole sodium and domperidone according to the following formula:

[0051] Omeprazole Sodium 10g

[0052] Domperidone 15g

[0053] Glucose 12g

[0054] Sodium edetate 0.8g

[0055] Sodium chloride 0.4 g

[0056] Appropriate amount of sodium hydroxide

[0057] Its preparation method is with embodiment 1.

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PUM

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Abstract

The invention discloses an Omeprazole sodium and domperidone injection, wherein the active constituents include Omeprazole sodium and domperidone by the weight ratio of 4:1-2:3, the injection also comprises excipient and stabilizing agent. The injection can be used for treating gastric ulcer, duodenal ulcer, stomach and gullet reverse-current, and functional dyspepsia.

Description

technical field [0001] The present invention relates to a kind of combination preparation of omeprazole and domperidone, more specifically, [0002] The invention relates to an injection containing omeprazole and domperidone. Background technique [0003] Omeprazole is a proton pump inhibitor (PPI) that blocks gastric acid secretion from various causes. After PPI enters the human body, the action time can reach more than 24 hours, so PPI's acid suppression intensity is strong and lasts for a long time, and it can effectively relieve acid reflux, heartburn and other symptoms of gastroesophageal reflux disease clinically. [0004] In the prior art, a large number of technologies about omeprazole preparation form, compound form and the like are disclosed. For example, Chinese patent application 95194038.4 discloses a new oral pharmaceutical preparation containing omeprazole magnesium salt wrapped by one or more enteric coating layers and a preparation method of the preparatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61K9/19A61P1/14A61K31/4439
Inventor 刘春平康秋萍李绍安李云霞
Owner 张志生
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