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Process for preparing nanometer fiber for packaging medicine or growth factor

A growth factor and drug technology, applied in the field of biomedical materials, can solve problems such as easy inactivation and instability, and achieve the effects of convenient operation, high porosity, and simple equipment

Inactive Publication Date: 2006-02-15
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since growth factors and some drugs are easily inactivated and unstable in the environment, this method still has certain limitations.

Method used

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  • Process for preparing nanometer fiber for packaging medicine or growth factor
  • Process for preparing nanometer fiber for packaging medicine or growth factor
  • Process for preparing nanometer fiber for packaging medicine or growth factor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) preparation polylactic acid mass concentration is the solution of 10%, and solvent is the mixed solvent of dichloromethane and DMF (1.5 / 1);

[0031] (2) prepare PEG concentration as 20% solution, solvent is acetone, add BMP-2 in the solution, concentration is 1% of polymer;

[0032] (3) Directly inject the solution (1) into the outer spray barrel (such as figure 1 ), the solution (2) is placed in the syringe connected to the metering pump (such as figure 1 ) for coaxial spinning to prepare a growth factor slow-release tissue engineering scaffold with an axial structure.

Embodiment 2

[0034] (1) preparation polylactic acid mass concentration is the solution of 10%, and solvent is the mixed solvent of dichloromethane and DMF (1.5 / 1);

[0035] (2) prepare PLA-PEG concentration as 20% solution, solvent is acetone, add BMP-2 in the solution, concentration is 1% of polymer;

[0036] (3) The solution (1) is directly injected into the outer spray cylinder, the solution (2) is placed in a syringe connected to a metering pump, and coaxial spinning is performed to prepare a growth factor sustained-release tissue engineering scaffold with an axial structure.

Embodiment 3

[0038] (1) preparation polylactic acid mass concentration is the solution of 10%, and solvent is the mixed solvent of dichloromethane and DMF (1.5 / 1);

[0039] (2) prepare PLA-PEG concentration as 20% solution, solvent is acetone, add BMP-2 in the solution, concentration is 1% of polymer;

[0040] (3) The solution (1) is directly injected into the outer spray cylinder, the solution (2) is placed in a syringe connected to a metering pump, and coaxial spinning is performed to prepare a growth factor sustained-release tissue engineering scaffold with an axial structure.

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Abstract

Disclosed is a process for preparing nanometer fiber for packaging medicine or growth factor, which comprises compounding biologically degradable polymer material with medicament or growth factor, coating the medicament or growth factor into nano fabrics by utilizing electrostatic spinning technology, thus forming nano fabric slow release system with an axial structure.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of nanofiber materials wrapped with drugs or growth factors. Background technique [0002] Growth factors are proteinaceous substances that have biological effects such as inducing and stimulating cell proliferation and maintaining cell survival. They are of great significance in promoting cell proliferation, repair and regeneration of tissues or organs, and play an important role in tissue engineering. However, all kinds of growth factors are polypeptide protein substances, which are easy to lose their biological activity in the presence of water and at room temperature. If it is directly injected into the body, the growth factor will be rapidly diffused and degraded within a day, and cannot play a long-term role in promoting the recovery of defective tissue. Therefore, how to maintain and prolong the biological activity of growth f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K9/00A61K45/00A61K38/18D01D1/02A61K47/34
Inventor 任杰诸静顾书英任天斌
Owner TONGJI UNIV
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