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Medicinal composition contg. ginseng secondary glycosides, prepn. method and application thereof

A technology of total ginseng secondary glycosides and compositions, which are applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as weak action intensity, increase oxygen supply, promote the opening of collateral circulation, improve the The effect of coronary flow

Active Publication Date: 2006-01-25
SHANGHAI HONGYITANG BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] These secondary saponins have many new activities, for example: ginsenosides Rh1, Rh2, and Rg3 have obvious anticancer activity, can induce redifferentiation of cancer cells, and can induce cancer cells to redifferentiate into healthy cells, while other saponin monomers have No such effect, or weaker effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] Take 10 kg of fibrous root section of ginseng, and use 70% ethanol to reflux extract 3 times, each time with 5 times the amount of solvent, each time for 3 hours. The combined extracts were concentrated under reduced pressure. Add an equal volume of 99% glacial acetic acid to the concentrated solution, and hydrolyze at 97-99°C for 5 hours. Add an equal volume of water to the hydrolyzate and pass it through a D101 macroporous resin column. After loading the sample, eluted with water until nearly colorless, then eluted with 0.5% sodium hydroxide, eluted with water until neutral, eluted with 20% ethanol, and finally eluted with 70% ethanol, collected the 70% ethanol eluate, Concentrate under reduced pressure to a fluid extract, and vacuum-dry at 70°C to obtain 0.56 kg of total ginsenoside extract. Measure the content of each active ingredient with high pressure liquid chromatography: 20-(S)-Rg3 is 9.0%, 20-(R)-Rg3 is 9.0%, 20-(S)-Rg2 is 2.1%, 20-(Rg )-Rg2 was 2.1%, 20-(...

Embodiment 2

[0110] Take 10 kg of ginseng decoction pieces, and extract 3 times with 70% ethanol under reflux, each time with 6 times the amount of solvent, each time for 3 hours. The combined extracts were concentrated under reduced pressure. Add an equal volume of 0.1% hydrochloric acid to the concentrated solution, and hydrolyze at 55-57°C for 5 hours. Add an equal volume of water to the hydrolyzate, and pass through the D2 macroporous resin column. After the sample is loaded, it is eluted with water until it is nearly colorless, then eluted with 1.5% sodium hydroxide, then eluted with water until neutral, then eluted with 25% ethanol, and finally eluted with 70% ethanol, and the 70% ethanol eluate is collected. Concentrate under reduced pressure to a fluid extract, and dry in vacuum at 70°C to obtain 0.35 kg of total ginseng glycosides extract. Measure the content of each active ingredient with high pressure liquid chromatography: 20-(S)-Rg3 is 8.8%, 20-(R)-Rg3 is 8.8%, 20-(S)-Rg2 is...

Embodiment 3

[0112]Take 10 kg of Radix Notoginseng decoction pieces, and extract 3 times with 70% ethanol under reflux, each time with 5 times the amount of solvent, each time for 3 hours. The combined extracts were concentrated under reduced pressure. Add an equal volume of 99% glacial acetic acid to the concentrated solution, and hydrolyze at 97-99°C for 5 hours. Add an equal volume of water to the hydrolyzate, and pass through the DM2 macroporous resin column. After the sample is loaded, it is eluted with water until it is nearly colorless, then eluted with 3.5% sodium hydroxide, then eluted with water until neutral, then eluted with 20% ethanol, and finally eluted with 75% ethanol, and the 75% ethanol eluate is collected. Concentrate under reduced pressure to liquid extract, and dry in vacuum at 70°C to obtain 0.38 kg of total ginsenoside extract. Measure the content of each active ingredient with high pressure liquid chromatography: 20-(S)-Rg3 is 5.7%, 20-(R)-Rg3 is 5.7%, 20-(S)-Rg2...

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PUM

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Abstract

A hypopanaxin composition for treating cardialgia, myocardial ischema and hemorrhagic shock contains such active components as 20-(S)-Rg3, 20-(R)-Rg3, 20-(R)-Rg2, 20-(S)-Rg2, 20-(S)-Rh1 and 20-(R)-Rh1. It is prepared from the ginseng family of plants through extracting, acidolyzing and using macroreticulr resin to separate, purify and concentrate.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing effective parts of ginseng and its preparation method and application, in particular to a pharmaceutical composition of total ginseng glycosides, its preparation method and application. Background technique [0002] Ginseng is an important medicine for invigorating Qi in traditional Chinese medicine. Nature, flavor and meridian distribution: sweet, slightly bitter, flat. Functions and indications: tonify vital energy, restore pulse and solidify, invigorate the spleen and lung, promote body fluid, and soothe the nerves. For physical weakness, cold limbs, slight pulse, spleen deficiency, lack of food, lung deficiency, wheezing and coughing, body fluid wound thirst, internal heat and thirst, prolonged illness and deficiency, palpitations and insomnia, impotence and cold uterus; heart failure, cardiogenic shock. [0003] Traditional Chinese medicine and integrated traditional Chinese and We...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/704A61P9/10
Inventor 孔从新罗何生赵咏丽
Owner SHANGHAI HONGYITANG BIOPHARM CO LTD
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