Oral adhering piece for treating oral exulceratio, and its prepn. method
A technology for oral ulcers and adhesive sheets, which is applied to the oral adhesive sheet for treating oral ulcers and the field of preparation thereof, can solve the problems of short retention time of the gel, failure to achieve treatment, dilution of the gel, etc., so as to reduce systemic side effects. Response, increased duration of action, effect of dose reduction
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Embodiment 1
[0033] 1. Components:
[0034] Main drug: Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF), which is a stock solution prepared by bacterial fermentation and column chromatography according to the "China Biological Products Regulations" (2000 edition).
[0035] Stabilizers: propylene glycol, human serum albumin, and lactose are commercially available products of pharmaceutical grade.
[0036] Transdermal absorption agent: Sodium deoxycholate and oleic acid are commercially available products of pharmaceutical grade.
[0037] Adhesive agent: Carbomer and magnesium stearate are commercially available products of pharmaceutical grade.
[0038] Auxiliary materials for the protective layer: acrylic resin, polyvinyl alcohol 17-88, all of which are commercially available.
[0039] 2. Prepare 1000 tablets of the main drug and auxiliary materials:
[0040] GM-CSF: 0.1g Propylene Glycol: 5.0g
[0041] Human albumin: 5.0g Lactose: 40.0g
[0042] Sodium deox...
Embodiment 2
[0054] 1. Components:
[0055] Main drug: Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF), which is a stock solution prepared by bacterial fermentation and column chromatography according to the "China Biological Products Regulations" (2000 edition).
[0056] Stabilizers: Glycerin, lactose, and hyaluronic acid are commercially available products of pharmaceutical grade.
[0057] Transdermal absorbent: lecithin and oleic acid are commercially available products of pharmaceutical grade.
[0058] Adhesive agent: Carbomer and magnesium stearate are commercially available products of pharmaceutical grade.
[0059] Auxiliary materials for the protective layer: polyvinyl alcohol 17-88, dioctyl phthalate, and yellow pigment are all commercially available products.
[0060] 2. Prepare 1000 tablets of the main drug and auxiliary materials:
[0061] GM-CSF: 0.3g Glycerin: 2.0g
[0062] Hyaluronic Acid: 5.0g Lactose: 30.1g
[0063] Lecithin: 0.1g Oleic aci...
Embodiment 3
[0075] 1. Components:
[0076] Main drug: Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF), which is a stock solution prepared by bacterial fermentation and column chromatography according to the "China Biological Products Regulations" (2000 edition).
[0077] Stabilizer: human albumin, vitamin B2, lactose, and sodium alginate are commercially available products of pharmaceutical grade.
[0078] Transdermal absorption agent: lecithin and polysorbate 80 are commercially available products of pharmaceutical grade.
[0079]Adhesives: Carbomer, hydroxypropyl cellulose, and magnesium stearate are all pharmaceutical-grade commercially available products. Auxiliary materials for the protective layer: acrylic resin, polyvinyl alcohol 17-88, glycerin, dioctyl phthalate, and yellow pigment are all commercially available products.
[0080] 2. Prepare 1000 tablets of the main drug and auxiliary materials:
[0081] GM-CSF: 0.05g
[0082] Human Albumin: 2.0g V...
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