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Use of medicinal composition in preparing medicine for treating cardiocytes fading

A cardiomyocyte apoptosis and composition technology, applied in the field of medicine, can solve the problem of cardiomyocyte apoptosis in compound Danshen dripping pills that has not yet been discovered

Active Publication Date: 2006-01-04
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on the synergistic treatment of cardiomyocyte apoptosis by compound Danshen dripping pills.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] 1. Formula dosage: 41.06g of Salvia miltiorrhiza, 8.03g of notoginseng, 0.46g of borneol, 18g of polyethylene glycol-6000 as an auxiliary material, made into 1000 drop pills.

[0065] 2. Extraction of Salvia miltiorrhiza and Panax notoginseng: Take the crushed Danshen and Panax notoginseng medicinal materials into the extraction tank, add 5 times the amount of water, decoct for 2 hours, filter, and extract the dregs for the second time, add 4 times the amount water, decoct for 1 hour, filter, discard the dregs, and combine the filtrate. The filtrate is concentrated under reduced pressure until the ratio of medicinal liquid volume (L) to medicinal material weight (Kg) is 1:0.9-1.1, slowly add 95% ethanol to make the medicinal liquid alcohol content 69-71%, and let it stand for 12 hours. The supernatant of the medicinal solution after alcohol precipitation is taken, filtered, ethanol is recovered from the filtrate, and concentrated into an extract with a relative density ...

Embodiment 2

[0068] 1. Formula dosage: Salvia miltiorrhiza 31.12g, Panax notoginseng 9.21g, borneol 0.50g, auxiliary material polyethylene glycol-6000 20g, made into 1000 drop pills.

[0069] 2. The extraction of Salvia Miltiorrhiza and Panax notoginseng as well as product preparation and characteristics are the same as in Example 1.

Embodiment 3

[0071] 1. Formula dosage: Salvia miltiorrhiza 59.36g, Panax notoginseng 6.38g, borneol 0.34g, auxiliary material is polyethylene glycol-6000 21g, made into 1000 drop pills.

[0072] 2. The extraction of Salvia Miltiorrhiza and Panax notoginseng as well as product preparation and characteristics are the same as in Example 1.

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition in preparing medicine for treating myocardial apoptosis. The experiments of administrating the medicine composition to spontaneous hypertension rats, measuring the left venticle thickening index, and radioimmunoassay measuring the local Ang II concentration in cardiac muscle and blood plasma and the aldosterone concentration in blood plasma show that the said medicine composition can lower SHR myocardial apoptosis and reduce left venticle thickness when used alone or together with fosinopril.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a pharmaceutical composition in the preparation of medicines for treating cardiomyocyte apoptosis. Background technique [0002] Apoptosis, also known as programmed cell death (PCD), is an orderly non-inflammatory cell death regulated by genes caused by local physiological or pathological stimuli. Ken et al first proposed this concept in 1972, but because the apoptosis process is short-lived and difficult to detect, it was not until the 1980s that people began to conduct extensive research on the apoptosis of various tissues and organs. [0003] In recent years, new breakthroughs have been made in the study of cardiomyocyte apoptosis, which has opened up a new way for people to explore the pathological mechanism and drug prevention and treatment of various heart diseases. Normal adult cardiomyocytes are generally considered as hig...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P9/12A61P9/00
Inventor 陈金水谢文艳吴天敏郑军郭治昕
Owner TIANJIN TASLY PHARMA CO LTD
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