Method for extracting curcumcnol, antifertility drug with curcumenol as main active ingredient for rats

An extraction method and a drug technology, which are applied in the field of preparation of drugs that cause infertility in mice, can solve the problems of being unsuitable for industrial production, affecting the application of curcumol, and high production costs, so as to maintain biodiversity, human and animal safety, and low production costs. Effect

Active Publication Date: 2005-10-26
YANBIAN TIANBAO BIOLOGICS
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Curcumol is the extract of zedoary. The conventional method is to use zedoary oil to separate and prepare by column chromatography. The output rate is extr...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] After pulverizing the zedoary, distill it with steam under normal pressure at about 100°C to separate the zedoary oil, further rectify, the temperature at the bottom of the kettle is 140°C, the reflux ratio is 2 to 1 under the vacuum condition of 400-500 Pa, and the temperature at the top of the tower is 106°C Remove borneol, elemene and other low-boiling substances, take the bottom of the kettle, cool and filter to obtain crystals, add an appropriate amount of petroleum ether with a boiling range of 30-60°C to wash 3 times, filter and extract the crude curcumol, add 4 times The ethanol of volume is heated to 80 ℃ and dissolves completely, drops into the gac of 0.1% by weight, stirs evenly, filters while hot and gets filtrate, obtains crystallization as curcumol of the present invention after cooling.

Embodiment 2

[0017] After pulverizing the zedoary, distill it with steam under normal pressure, separate the zedoary oil, further rectify, the temperature at the bottom of the kettle is 145°C, under the vacuum condition of 400-500 Pa, the reflux ratio is 3 to 1, and the temperature at the top of the tower is 106°C to remove the borneol, For substances with low boiling point such as elemene, take the bottom of the kettle, cool and filter to obtain a crude crystal, add 6 times the volume of ethanol, heat to 80°C to completely dissolve, add 0.3% by weight of activated carbon, stir evenly, and filter while hot to get the filtrate , after cooling, the crystallization is curcumol of the present invention.

Embodiment 3

[0019] Weigh 1 kg of curcumol and add 5 kg of ethanol to dissolve, 100 kg of cottonseed meal is pulverized into 60-mesh fine powder, the two raw materials are mixed evenly, and bait is made after granulation.

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Abstract

The extraction method of curcumenol includes the following steps: pulverizing rhizoma curcumae, using steam to make distillation at normal pressure and making separation to obtain oil of aromatic turmeric, further rectification under the condition of vacuum, removing low boiling point substances of borneol and element, etc. taking out bottoms, cooling, filtering to obtain crystal crude product, adding ethyl alcohol to dissolve it, adding active carbon, uniformly stirring, filtering and cooling so as to obtain curcumenol, utilizing curcumenol and cotton seed cake to make bait; adding grain crops of corn or bran and soybean cake, uniformly mixing them, granulating and forming so as to obtain rat antifertility drug.

Description

technical field [0001] The invention discloses a method for extracting curcumol, and also provides an anti-fertility drug for mice with the curcumol as a main active ingredient, and relates to the technical field of preparation of drugs that cause infertility in mice. Background technique [0002] At present, forest rodents and rabbits are generally only managed by means of hunting or drug poisoning. The means are primitive, poor in science, and the quantity is difficult to grasp. It also poses a great threat to humans. [0003] The curcuma involved in the present invention is the rhizome of Curcuma aromatica Salisb. Curcumol is the extract of zedoary. The conventional method is to use zedoary oil to separate and prepare by column chromatography. The output rate is extremely low and the preparation cost is high. It is not suitable for industrial production and cannot be industrialized, which affects the application of curcumol. . Invention content: [0004] The inventio...

Claims

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Application Information

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IPC IPC(8): C07D493/08
Inventor 郭俊平赵日良戴坚张春美郭俊杰郭俊玉刘淑清
Owner YANBIAN TIANBAO BIOLOGICS
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