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Human vaccine containing bee glue adjuvent and its preparing method

A vaccine preparation and glue adjuvant technology, applied in the field of biological drugs, can solve the problems of lack of biological drugs, development and application in the field of biochemistry, limited application of propolis, etc., and achieve the effect of no toxic side effects, safe and reliable chemical residues, and no chemical residues

Inactive Publication Date: 2005-10-19
TIANCHONG BIO PHARMACY INST LIAONING PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of propolis is currently limited, limited to oral administration, and has not yet been developed and applied in the field of biochemistry, and it is even more deficient in biological medicine.

Method used

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  • Human vaccine containing bee glue adjuvent and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0049] Example 1, human vaccine containing propolis adjuvant, influenza virus vaccine containing propolis adjuvant, per milliliter containing propolis adjuvant is 5 mg; according to the nanometer scale of the immunologically active antigen of the influenza virus vaccine, it is greater than 5 nanometers of the immunologically active antigen.

example 2

[0050] Example 2. Crude propolis→freezing→crushing→ethanol extraction→filtrate→activated carbon filtration→continuous centrifugation→removing activated carbon→removing precipitate→adding vaccine→nanotechnology treatment→ultrafiltration→vacuum concentration→human vaccine containing propolis adjuvant→frozen Save it.

example 3

[0051] Example 3: Take 10,000 ml of whole influenza virus after hydrostatic pressure inactivation or nano split influenza virus or purified subunit antigen of nano split influenza virus or influenza virus nasal spray antigen, and add it to propolis adjuvant so that each ml of vaccine contains 5 propolis Milligrams and fully mixed, and then according to the nanoscale size of each vaccine immunologically active antigen, it is generally selected to be 5 nanometers larger than the immunologically active antigen, and the adjusted nano-collider is used for nanotechnology processing so that the processed high-speed fluid particles are instantly cracked, The functions of pulverization, dispersion, emulsification, catalysis and synthesis are integrated to further improve the immunogenicity and antiseptic functions of propolis as a vaccine immune adjuvant to ensure the safety and stability of the vaccine.

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Abstract

The human vaccine contains bee glue adjuvant in the size 5-10 nm larger than active immunological antigen of 2-20 mg in each milliliter. The human vaccine preparing process includes the steps of freezing coarse bee glue, crushing, extracting, filtering, continuous centrifuging, eliminating residue, eliminating precipitate, adding vaccine, nanometer processing, ultrafiltering, vacuum concentrating to obtain human vaccine containing bee glue adjuvant and freeze to store. The human vaccine has the functions of inactivator, preservative, immunopotentiator, stabilizer and promoter. The present invention has the advantages of being safe and reliable, no chemical residue, no toxic side effect, fast formation of immunological antibody and long immune period.

Description

[0001] Field [0002] The present invention relates to vaccines and methods for their preparation. Specifically, it involves the extraction and purification of propolis to meet the requirements of "three removals and one dissolution" (deleading, desensitization, decolorization, and soluble in water); and a human vaccine containing propolis adjuvant cracked by nanotechnology and its preparation The method belongs to the field of biopharmaceuticals. Background technique [0003] Propolis is the gum (resin substance) collected by bees from the new branches and leaves buds or bark or flower buds of glue source plants, mixed with wax from the secretions of bee palate glands and wax glands. It is a fragrant opaque glue. It is a glue-like substance that is repeatedly processed by bees and applied to the entrance and inner wall of the hive to maintain a relatively sterile state in the hive. So propolis is the material basis for the life extension of bees. Before the queen bee lays ...

Claims

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Application Information

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IPC IPC(8): A61K39/39
Inventor 苟仕金苟鸿鹰王成余
Owner TIANCHONG BIO PHARMACY INST LIAONING PROV
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