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Preparing anti-inflammatory component of bighead atractylodes rhizome volatile oil part and use in preparing anti-inflammatory medicines

A technique for the volatile oil of Atractylodes Rhizoma Atractylodes Rhizome and the technology of Atractylodes Rhizoma Atractylodes Rhizome, which is applied in the preparation of anti-inflammatory components of the volatile oil of Atractylodes Rhizoma Atractylodes Rhizome, and in the field of preparation of anti-inflammatory drugs, and can solve the problems that the preparation method of the anti-inflammatory effect of the volatile oil of Atractylodes Rhizome has not been reported.

Inactive Publication Date: 2005-10-19
XI AN JIAOTONG UNIV
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Problems solved by technology

However, the anti-inflammatory effect of the volatile oil part of Atractylodes Rhizome and the preparation method of the anti-inflammatory components of the volatile oil part of Atractylodes Rhizome have not been reported

Method used

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  • Preparing anti-inflammatory component of bighead atractylodes rhizome volatile oil part and use in preparing anti-inflammatory medicines

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Embodiment Construction

[0008] One, the preparation technology of Atractylodes macrocephala volatile oil

[0009] 1 instrument

[0010] HA220-50-06 supercritical extraction device (Nantong Huaan Supercritical Extraction Co., Ltd.); LC-10ATvp high performance liquid chromatography system (Shimadzu Corporation, Japan).

[0011] 2 Preparation process

[0012] Take Atractylodes macrocephala Koidz (Atractylodes macrocephala Koidz) decoction pieces, pulverize, sieve (60 mesh), weigh 2kg of the powder, and place it in a 5L supercritical extraction kettle. Turn on the refrigeration device, the heating device of the extraction kettle and the separation kettle, and turn on the compression pump after reaching the set temperature to keep the pressure of the extraction kettle at 20.0MPa, the temperature at 50°C, and 40kg / h of CO 2 Flow rate cycle extraction. The pressure and temperature of the separation tank were 10.0MPa and 30°C, respectively, and the extraction cycle was 3h. A yellow oil was obtained with ...

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Abstract

The present invention discloses the preparation process of anti-inflammatory component from volatile bighead atractylodes rhizome oil and its use in preparing anti-inflammatory medicine. The preparation process includes supercritical CO2 extraction to obtain volatile white atractylodes rhizome oil; silicon gel chromatography and elution to obtain four different eluted parts corresponding to petroleum ether, petroleum ether-ethyl ether (BZC-2), ethyl ether and methanol separately; and final reverse C18 silicon gel column chromatography of BZC-2 part to obtain butenolide I and bighead atractylodes polyacetylene. Pharmacodynamical research shows that butenolide I and bighead atractylodes polyacetylene and the BZC-2 part have obvious anti-inflammatory activity.

Description

technical field [0001] The invention relates to the anti-inflammatory effect of the volatile oil extracted and separated from the Chinese medicinal material Atractylodes Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Atractylodes Rhizoma Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes and its application in preparing anti-inflammatory drugs. technical background [0002] Atractylodes macrocephala Koidz is a plant of the genus Atractylodes in the family Compositae. It has the effects of invigorating the spleen and replenishing qi. It is used to treat diseases such as deficiency of the spleen, lack of food, edema, spontaneous perspiration, and restless fetal movement. Atractylodes macrocephala mainly contains sesquiterpenoids and alkyne compounds. Yamahara et al. (Yakugaku Zasshi 1977, 97, 873-879) found...

Claims

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Application Information

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IPC IPC(8): A61P29/00
Inventor 贺浪冲李翠芹董海燕杨林王嫦鹤
Owner XI AN JIAOTONG UNIV
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