Skin plaster containing aceclofenac

A technology of aceclofenac and patches, applied in the directions of medical preparations containing active ingredients, anti-inflammatory agents, non-central analgesics, etc. The research on the composition of fenac transdermal preparations has achieved the effect of overcoming the difficulty of accurately controlling the dosage, facilitating localized treatment and overcoming adverse reactions.

Inactive Publication Date: 2005-10-19
西安东盛集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are literatures reporting aceclofenac ointment based on polyethylene glycol (Journal of China Pharmaceutical University, 1996, 27(12): 718-721), and literatures reporting diclofenac sodium and aceclofenac solution in vitro Research on transdermal absorption (Journal of China Pharmaceutical University, 2004, 35(4): 311-314), but no research was conducted on the composition of aceclofenac transdermal preparations, and no report on the efficacy of aceclofenac skin patches composition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: take polyisobutylene rubber as the preparation method of the patch containing aceclofenac of skeleton: get polyisobutylene and polyisobutyl butadiene mixture 100 weight parts, be dissolved in 400 weight parts chloroform, add vinegar chloride 5 parts by weight of fenac, dissolved and dispersed uniformly, coated, dried to evaporate the volatile solvent, compounded with a backing layer and an anti-adhesive layer, and cut into patches of suitable sizes according to dosage requirements.

Embodiment 2

[0051] Embodiment 2: take polyisoprene rubber as the preparation method of the skin patch containing aceclofenac of skeleton: get polyisoprene and polyisobutyl butadiene mixture 100 weight parts, dissolve in 400 In parts by weight of chloroform, add 28 parts by weight of aceclofenac, 6 parts by weight of mineral oil, 2 parts by weight of triethyl citrate, 1 part by weight of diethyl phthalate, 5 parts by weight of citric acid, and 3 parts by weight of peppermint oil Parts, 2 parts by weight of eucalyptus oil, dissolved and dispersed evenly, coated film, volatile solvent, composite backing layer, anti-adhesive layer, cut into patches of appropriate size according to dosage requirements.

Embodiment 3

[0052] Embodiment 3: take acrylate pressure-sensitive adhesive as the preparation method of the patch containing aceclofenac of skeleton; Get solid content and be 30% acrylate pressure-sensitive adhesive (ethyl acetate is solvent) 100 weight parts, add vinegar 5 parts by weight of clofenac, dissolved and dispersed uniformly, coated, dried to evaporate the volatile solvent, compounded with a backing layer and an anti-adhesive layer, and cut into patches of suitable sizes according to dosage requirements.

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PUM

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Abstract

The present invention relates to skin plaster, and a kind of local skin plaster containing acelofenac for treating and relieving osteoarthritis, rheumatoid arthritis, ankylosed rachitis and sciatica.

Description

technical field [0001] The present invention relates to a new dosage form of non-steroidal anti-inflammatory drugs, more specifically aceclofen, a drug used for treating and relieving osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and sciatica acid is a topical skin patch. Background technique [0002] Aceclofenac (aceclofenac) is a non-steroidal anti-inflammatory drug, the chemical name is [o-(2,6-dichloroaniline) phenyl] acetoacetic acid, which was first developed and listed by the Spanish Prudes Pharmaceutical Company in 1992. . Aceclofenac is a derivative of diclofenac sodium, which can reduce the biosynthesis of prostaglandins in the pain site by inhibiting cyclooxygenase and reduce the exudation of inflammatory mediators such as leukotrienes and bradykinin by inhibiting lipoxygenase, so as to reduce the local inflammatory response , Congestion and swelling of tissues, reduce the sensitization effect of inflammatory mediators to cause inflammation and p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/196A61P19/02A61P29/00
Inventor 姬海红景岗丁平田
Owner 西安东盛集团有限公司
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