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Self microemulsifying preparation of curcumin and its preparing process

A self-micro-emulsifying, curcumin technology, applied in the directions of antitoxins, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problems of less absorption, poor compliance, and unsatisfactory solubility, and achieve increased absorption, good adhesion, and biological improvement. The effect of utilization

Active Publication Date: 2005-10-19
山东淄博新达制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, curcumin is almost insoluble in water, and its solubility in various oils is not ideal, so it has little absorption through the gastrointestinal tract, low oral bioavailability, and injection administration is inconvenient to use, and patients cannot self-administer the drug, and the compliance is poor

Method used

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  • Self microemulsifying preparation of curcumin and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh emulsifier-OP (polyoxyethylene nonylphenol ether, G 34 h 62 o 11 , Molecular weight 648.85) 100g, add curcumin 2.5g, stir, and medicine is dissolved completely, add Polyethylene Glycol 400 35g, ethyl oleate 10g, high-speed stirring makes mixing, obtains curcumin self-microemulsification concentrate. Get 60 g of micropowder silica gel and 20 g of mannitol that have passed through a 100-mesh sieve, mix evenly with the above-mentioned concentrate, pass through a 20-mesh sieve to obtain granules, and pack 400 hard capsules.

Embodiment 2

[0027] Weigh 100 g of Tween-80, add 3 g of curcumin, heat to 40° C. to completely dissolve the drug, add 100 g of glycerin, 10 g of ethyl oleate, stir at high speed, and mix evenly to obtain curcumin self-microemulsifying concentrate. Take 200g of polyethylene glycol 4000, heat it in a water bath to 70°C to melt, quickly pour the above concentrated solution into polyethylene glycol 4000 and mix evenly, then put it into an ice-water bath to cool and solidify quickly. The obtained solid was pulverized and passed through a 18-mesh sieve to obtain granules, which were dried and packed into aluminum-plastic packaging bags to obtain 400 packets of granules.

Embodiment 3

[0029] Weigh 200g of Tween-80, 50g of PEG400, 25g of peanut oil, stir and mix evenly at high speed, add 2.5g of curcumin, stir to dissolve the medicine completely, obtain curcumin self-microemulsification concentrate, add appropriate amount of distilled water to form curcumin microemulsion 1000ml. Take lactose 200g and PVP through 80 mesh sieve k15 200g, mixed evenly with the above microemulsion, freeze-dried and passed through a 20-mesh sieve to obtain granules. The granules are subpackaged to obtain granules.

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Abstract

The self microemulsified curcumin preparation consists of curcumin, surfactant, co-surfactant, oil phase and solid adsorbent. The self microemulsified curcumin preparation may be prepared into capsule or granule for orally taking, and the capsule or granule under the action of gastrointestinal fluid may be self microemulsified to form liquid drops with size below 100 nm. Therefore, the present invention has increased curcumin solubility and absorption in gastrointestinal tract and raised bioavailability.

Description

(1) Technical field [0001] The invention relates to a curcumin self-microemulsifying preparation and a preparation method thereof. (2) Background technology [0002] Curcumin (curcumin) is a natural active ingredient extracted from the rhizomes of turmeric, curcuma, turmeric, etc. 21 h 20 o 6 . Pharmacological experiments have shown that in addition to anti-inflammatory, anti-cancer, and anti-oxidative effects, curcumin also has various pharmacological effects such as protecting the kidney, inhibiting pulmonary fibrosis, inhibiting liver fibrosis, helping muscle damage repair, treating cataracts, and anti-parasitic diseases , and the toxic and side effects are small, safe to use, and have good prospects for clinical application. However, curcumin is almost insoluble in water, and its solubility in various oils is not ideal, so it has little absorption through the gastrointestinal tract and low oral bioavailability, and injection administration is inconvenient to use, and...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/122A61P29/00A61P35/00A61P39/06
Inventor 翟光喜娄红祥崔晶
Owner 山东淄博新达制药有限公司
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