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Anti blocking biomembrane

A biofilm and anti-adhesion technology, applied in the types of packaging items, special packaging items, medical science, etc., can solve the problems of insufficient strength, difficulty in meeting the needs of intraoperative suturing, short, 24-48 hours, etc.

Active Publication Date: 2005-08-31
SHANGHAI HAOHAI BIOLOGICAL TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But Seprafilm  There are also very obvious defects: one is that the strength of the membrane is not enough, it is difficult to meet the needs of suturing during the operation, especially the operability is poor in a wet state; It turns into a gel and is degraded and absorbed in about a week
It is difficult to meet clinical needs for parts that require a longer duration of anti-adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: Put 0.015g of aluminum ammonium sulfate solid into 10ml of distilled water, make it dissolve at 60 ℃, be made into aluminum ammonium sulfate solution. Dissolve 0.1 g of carboxymethyl cellulose powder in the aluminum ammonium sulfate solution, stir rapidly until dissolved, then add 0.1 g of carboxymethyl chitosan powder and continue stirring until completely dissolved. Then add 0.8 ml of 10% glycerin and 0.14 ml of 0.25% glutaraldehyde and stir thoroughly. Then put the solution into a vacuum oven for degassing, and the vacuum pressure is 0.1mpa. Finally, the solution was poured into a 5cm×5cm stainless steel box for casting, and dried in an oven at 70°C to form a film.

Embodiment 2

[0013] Example 2.: Add 0.1 g of carboxymethyl cellulose and 0.1 g of carboxymethyl chitosan powders to 10 ml of distilled water in turn until completely dissolved. Then add 0.8 ml of 10% glycerin, 0.14 ml of 0.25% glutaraldehyde, and 0.015 g of aluminum ammonium sulfate solid and stir thoroughly. Then put the solution into a vacuum oven for degassing, and the vacuum pressure is 0.1mpa. Finally, the solution was poured into a 5cm×5cm stainless steel box for casting, and dried in an oven at 70°C to form a film.

[0014] The tensile strength of the biofilm was tested at room temperature using a CMT6202 tensile machine (Changchun No. 1 Machinery Manufacturing Factory). Cut the biofilm to a length of 40 mm and a width of 20 mm, and stretch it slowly at a speed of 20 mm / min to test the tensile strength of the film in a dry state. Then soak the same size membrane in distilled water for 1 hour to test the tensile strength of the membrane in wet state. After testing, the tensile str...

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Abstract

An antiadhesion iomembrane for wound and operation is prepared from carboxymethyl cellulose, carboxymethylchitosan, aluminium ammonium sulfate, glutaraldehyde glycerine and water.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, and relates to a biofilm for preventing trauma and postoperative adhesion. Background technique [0002] Surgical adhesions are common after surgical operations on the abdominal cavity, cardiovascular system, spine, joints, and tendons. Postoperative adhesions will not only affect the effect of surgery, but also lead to serious postoperative complications, and even make a successful operation fail. Therefore, preventing postoperative adhesions has always been a problem that researchers have been working hard to solve. Many researchers have used different materials to try to prevent scar formation and adhesion with tissue by physical or chemical methods, and the results obtained are different, but all have defects of one kind or another, such as poor anti-adhesion effect and cannot be completely resolved. Immunity, biodegradability issues, insufficient mechan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L33/08
Inventor 侯春林顾其胜肖海军
Owner SHANGHAI HAOHAI BIOLOGICAL TECH
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