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Combination of medication containing reductase inhibitor HMG CoA and Melatonin

A composition and technology of melatonin, applied in the field of medicine, can solve the problems of lowering OX-LDL level, blood lipid level without consistent effect, lowering, etc.

Inactive Publication Date: 2005-08-31
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] While statins can significantly reduce plasma triglycerides and plasma LDL, they can also significantly reduce the level of OX-LDL in animals. Melatonin alone has no significant effect on blood lipid levels. There are clinical studies in the literature. The serum LDL of some patients can be significantly lowered, but it has no consistent effect on the blood lipid level of patients with hyperlipidemia in general

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] lovastatin melatonin compound tablet

[0013] Prescription A

[0014] Melatonin 3g

[0015] Lactose 30g

[0016] Sodium carboxymethyl starch 30g

[0017] Microcrystalline Cellulose 18g

[0018] 6% PVP in absolute ethanol 100g

[0019] Magnesium Stearate 2g

[0020] Preparation Process:

[0021] Melatonin passes through a 100-mesh sieve, lactose, sodium carboxymethyl starch, and microcrystalline cellulose pass through a 80-mesh sieve, weighs the prescribed amount of melatonin, lactose, sodium carboxymethyl starch, and microcrystalline cellulose, mixes evenly, and adds Appropriate amount of 6% PVP ethanol solution is granulated, dried at 60° C., sieved with 16 meshes to dry the granules, and adding the prescribed amount of magnesium stearate to the dry granules. Prescription B

[0022] Lovastatin 10g

[0023] Hydroxypropyl Cellulose 15g

[0024] 10g pregelatinized starch

[0025...

Embodiment 2

[0030] Atorvastatin and Melatonin Combination Tablets

[0031] Melatonin 10g

[0032] Mannitol 10g

[0033] Lactose 40g

[0034] Microcrystalline Cellulose 20g

[0035] 6% PVP in 95% ethanol solution 120g

[0036] Magnesium stearate 2g

[0037] Preparation Process:

[0038] Melatonin passes through a 100-mesh sieve, mannitol, lactose, and microcrystalline cellulose pass through a 80-mesh sieve, weighs the prescribed amount of melatonin, mannitol, lactose, and microcrystalline cellulose, mixes evenly, and adds 95% of 6% PVP An appropriate amount of ethanol solution is granulated, dried at 60° C., sieved with a 16-mesh sieve to dry the granules, and adding a prescribed amount of magnesium stearate to the dry granules.

[0039] Atorvastatin 10g

[0040] Pregelatinized starch 50g

[0041] Mannitol 50g

[0042] Lactose 40g

[0043] 6% PVP in 95% ethanol solution 100g

[0044] ...

Embodiment 3

[0049] Simvastatin Melatonin Compound Capsules

[0050] Melatonin 5g

[0051] Simvastatin 10g

[0052] Lactose 20g

[0053] Microcrystalline Cellulose 60g

[0054] tert-butyl-4-hydroxyanisole (BHA) 0.05g

[0055] Micronized silica gel 5g

[0056] 6% PVP in 95% ethanol solution

[0057] Preparation Process:

[0058] Pass the melatonin, simvastatin, lactose, microcrystalline cellulose, tert-butyl-4-hydroxyanisole and micropowder silica gel in the prescription through a 100-mesh sieve, mix well, add 6% PVP in 95% ethanol solution Appropriate amount of granulation, drying at 60°C, granulation with 18 mesh sieve, and capsule filling.

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PUM

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Abstract

A composite medicine in the form of tablet, capsule, softgel, or dispersing tablet for preventing the atherosclerosis by cutting off the oxidization modification to low-density lipoprotein (LDL) and decreasing the LDL contains HMG-CoA reductase inhibitor (tatin-type medicine and melatonin.

Description

technical field [0001] The invention belongs to medical technology and relates to a more effective pharmaceutical composition for improving blood lipid. Background technique [0002] With the continuous development of medical science, people realize that the high content of cholesterol and fat is the basic cause of cardiovascular disease, and hyperlipidemia is the main risk factor of coronary heart disease and hypertension. Therefore, people began to focus on the development of blood lipid regulating drugs as the prevention and treatment of cardiovascular diseases. Since the late 1980s, a large number of blood lipid-lowering drugs have been launched, among which statins have been well received by people, and their clinical efficacy is unmatched by other types of blood lipid regulating drugs. Over the past ten years, the completion of several international large-scale coronary heart disease prevention and treatment trials has confirmed that statins can reduce the morbidity a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/366A61K31/4045A61K45/06A61P3/06A61P9/12
Inventor 孙勇
Owner LUNAN PHARMA GROUP CORPORATION
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