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Method for preparing super paramagnetic high polymer homogeneous microball

A technology of superparamagnetic and manufacturing methods, which is applied in the field of manufacturing magnetic polymer microspheres, can solve problems such as the inability to synthesize uniform magnetic microspheres, magnetic polymer microspheres, etc., achieve easy expansion of production, uniform distribution of magnetic content, and avoid collision effect

Inactive Publication Date: 2005-07-20
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the conventional polymerization reaction in the manufacture of magnetic polymer microspheres, which cannot synthesize uniform magnetic microspheres and the defects in the performance of the manufactured magnetic polymer microspheres, thereby providing a method using spray Method for manufacturing superparamagnetic polymer homogeneous microspheres by flow suspension polymerization

Method used

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  • Method for preparing super paramagnetic high polymer homogeneous microball
  • Method for preparing super paramagnetic high polymer homogeneous microball
  • Method for preparing super paramagnetic high polymer homogeneous microball

Examples

Experimental program
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Embodiment 1

[0047] The upper end of the oil phase storage tank 3 of the jet-flow suspension polymerization reaction device is connected with the nitrogen cylinder 1 through the first regulating valve 2, and connected with the spray nozzle 9 at the upper end of the polymerization reactor 11 through the second regulating valve 7 and the flow meter 8 The upper end of the oil phase storage tank 3 is equipped with a pressure gauge 4, a motor 5 and a safety valve 6, and the motor 5 drives the agitator to rotate; the polymerization reactor 11 is installed with a paddle agitator driven by the motor 10, and the upper end is installed with an automatically adjustable sprayer. For the nozzle 9, the distance between the nozzle 9 and the liquid surface of the water phase in the reaction kettle 11 can be adjusted to obtain droplets with different particle sizes; the diameter of the nozzle (9) is 10-100 μm.

[0048] 2. Improved co-precipitation method to produce hydrophobic Fe 3 o 4 Ferrofluid:

Embodiment 2

[0050] Add 0.098mol FeCl to a 1-liter stirred reactor filled with 800ml distilled water 2 4H 2 O and 0.196 mol FeCl 3 ·6H 2 O, heat up to 90°C, pour 30-40ml NH 3 ·H 2 O aqueous solution, after 2 minutes, start to press 0.5ml·min -1 Add about 20ml of stearic acid dropwise at a high speed until a clear supernatant is seen, continue to keep the temperature for 40min, and pour off the supernatant to obtain a black mass of Fe coated with stearic acid. 3 o 4 ferrofluid.

Embodiment 3

[0052] Add 0.25mol FeSO to a 1-liter stirred reactor filled with 500ml distilled water 4 ·7H 2 O, 0.49mol FeCl 3 ·6H 2 O, heat up to 70°C, pour 0.4mol Na 2 CO 3 50-60ml of aqueous solution, add 15ml of oleic acid dropwise within 30min, after the supernatant becomes clear, raise the temperature to 80°C for 1 hour, pour off the supernatant to obtain Fe 3 o 4 ferrofluid.

[0053] 3. Manufacture of superparamagnetic polymer homogeneous microspheres by jet-flow suspension polymerization:

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Abstract

The present invention provides the making process of homogeneous superparamagnetic polymer microballoon. Nanometer Fe3O4 grain prepared in coprecipitation process has its surface coated with oleophilic layer to form hydrophobic Fe3O4 magnetic fluid, and the magnetic fluid is dissolved in hydrophobic olefin monomer and oil soluble initiator via stirring to form homogeneous dispersive oil phase fluid. The oil phase fluid is crushed and dispersed into homogeneous oil drops in a spouting suspension polymerization process so as to form homogeneous O / W suspension in water phase. Under certain polymerizing temperature, oil drop is cured fast and constant temperature polymerized into homogeneous size superparamagnetic polymer microballoon. The superparamagnetic polymer microballoon has size of about 10 micron, specific saturation magnetic intensity of 15-20 emu / g, homogeneous magnetic content, stable chemical property and latent application in biological separation.

Description

technical field [0001] The invention relates to a method for manufacturing magnetic polymer microspheres, in particular to a method for manufacturing uniform superparamagnetic polymer microspheres by a jet-flow suspension polymerization method. Background technique [0002] In recent years, magnetic polymer microspheres have shown unique advantages in bioseparation engineering and biomedical engineering, especially in the application fields of cell separation, immobilized enzymes, immunoassays, targeted drugs, separation and purification of proteins and enzymes, etc. The prospect of human application is one of the hot topics of current research. [0003] The prior art methods for synthesizing magnetic polymer microspheres mainly include polymer embedding, chemical conversion and monomer polymerization. The performance of magnetic microspheres synthesized by chemical conversion method is better, but its manufacturing process is cumbersome, resulting in greatly increased prod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F2/10C08F2/44C08K9/00C08L23/00
Inventor 阳承利邢建民官月平刘俊果安振涛刘会洲
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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