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Method for correlating gene expression profiles with protein expression profiles

A gene expression profiling and associated technology, applied in the field of associating gene expression profiling with protein expression profiling

Inactive Publication Date: 2005-07-06
CIPHERGEN BIOSYSTEMS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] At the same time, current protein expression profiling methods, such as mass spectrometry, 2D gel electrophoresis, and chromatography, have some limitations in sensitivity and resolution (see, for example, Pandey & Mann, Nature 405:837- 846 (2000)

Method used

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Embodiment Construction

[0015] introduction

[0016] The present invention provides methods that combine the preparation of RNA and protein expression profiles for the identification of genes and proteins expressed by cells under different conditions, such as different phases of the cell cycle, changing environmental conditions (such as ion influx or efflux; exposure to: toxins; drugs; ligands; such as hormones, cytokines, or chemokines; or pathogens such as viruses, bacteria, protozoa, or fungi), altered pathological conditions such as cancer, maturation and Different stages in the differentiation process, different stages in the development of organisms, in the process of response (such as inflammation), different tissue types or organs, different pathological conditions such as cancer or autoimmune diseases, between individuals with different phenotypic traits , such as between individuals who responded to a particular drug and those who did not, and so on. For example, the method of the present ...

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Abstract

The present invention relates to methods of correlating gene and protein expression in cells.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to USSN 60 / 269,772, filed February 16, 2001, which is hereby incorporated by reference in its entirety. [0003] Statement Concerning Rights to Inventions Made Under Federally Funded Research and Development [0004] Not applicable. Background of the invention [0005] Genomics is the study of all the genes (genome) of a species, and the function and activity of those genes in different and the same cells, over time and at various stages of development, under various environmental conditions. Different gene functions and activities play an important role in the development of specialized activities of cells in the body and the transformation of healthy cells into pathological cells. [0006] The expression of genetic information in cells is carried out by transcribing the intermediate molecule mRNA. Cells translate expressed mRNA into polypeptides...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62C12N15/09C12Q1/68C12Q1/6809G01N27/447G01N27/64G01N33/50G01N33/53G01N37/00
CPCC12Q1/6809Y10T436/24C12Q1/68
Inventor W·E·里奇T·W·赫琴斯
Owner CIPHERGEN BIOSYSTEMS INC
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