Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Bicarbonate hemodialysis agent without acetic acid

A technology of bicarbonate and dialysis agent, applied in the field of hemodialysis agent, can solve the problems of high price of glycylglycine, restricting the widespread use, etc., and achieve the effects of protecting normal cells and residual renal function, low price, and overcoming adverse effects.

Active Publication Date: 2005-07-06
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glycylglycine is expensive, which restricts its widespread clinical use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bicarbonate hemodialysis agent without acetic acid

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0044] 1. Example 1: A component sodium chloride (NaCl) 1610g

[0045] Potassium chloride (KCl) 41.2g

[0046] Calcium Chloride (CaCl 2 2H 2 O) 97.0g

[0047] Magnesium Chloride (MgCl 2 ·6H 2 O) 59.9g

[0048] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 197.2g

[0049] B component sodium bicarbonate (NaHCO 3 ) 660.1g

[0050] Sodium chloride (NaCl) 304.9g

[0051] According to the above formula, prepare the solid preparations of components A and B or add water to dissolve and dilute to 10L to make liquid preparations. Mix liquid A, liquid B and water according to the ratio of 1:1.83:34 on the machine, and the final concentration of each ion (mmol / L) is:

[0052] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0053] 139.7 1.5 1.8 0.8 112.2 4.8 39.0

example 2

[0054] 2. Example 2: A component sodium chloride (NaCl) 2168.1g

[0055] Potassium chloride (KCl) 78.3g

[0056] Calcium Chloride (CaCl 2 2H 2 O) 77.2g

[0057] Magnesium Chloride (MgCl 2 ·6H 2 O) 24.9g

[0058] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 97.6g

[0059] B component sodium bicarbonate (NaHCO 3 ) 700g

[0060] Sodium chloride (NaCl) 0

[0061] According to the above formula, prepare the solid preparations of components A and B or add water to dissolve and dilute to 10L to make liquid preparations. Mix liquid A, liquid B and water according to the ratio of 1:1.26:32.74 on the machine, and the final concentration of each ion (mmol / L) is:

[0062] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0063] 136 3.0 1.5 0.35 115.2 2.5 30.0

example 3

[0064] 3. Example 3: A component sodium chloride (NaCl) 1721.9g

[0065] Potassium chloride (KCl) 41.2g

[0066] Calcium Chloride (CaCl 2 2H 2 O) 81.2g

[0067] Magnesium Chloride (MgCl 2 ·6H 2 O) 37.5g

[0068] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 123.2g

[0069] B component sodium bicarbonate (NaHCO 3 ) 659g

[0070] Sodium chloride (NaCl) 282g

[0071] According to the above formula, prepare the solid preparations of components A and B or add water to dissolve and dilute to 10L to make liquid preparations. Mix liquid A, liquid B and water according to the ratio of 1:1.83:34 on the machine, and the final concentration of each ion (mmol / L) is:

[0072] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0073] 143 1.5 1.5 0.5 112.5 3.0 39.0

[0074] Get the formula of embodiment 3 and carry out stability test (accelerate 6 months and keep sample for a long time...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an acetate acid free hemodialysis agent of bicarbonate. The hemodialysis agent is composed of constituent A and constituent B, constituent A: sodium chloride 77%-94%, potassium chloride 0%-4%, calcium chloride 2%-6%, magnesium chloride 1%-3%, glycine hydrochloride 3%-10%. constituent B: sodium bicarbonate 65%-100%, sodium chloride 0%-35%.

Description

technical field [0001] The invention relates to a hemodialysis agent in blood purification treatment, in particular to a bicarbonate hemodialysis agent including solid and liquid formulations. Background technique [0002] Currently commonly used bicarbonate hemodialysis preparations are divided into two components, A and B. The A component is mainly composed of sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl) 2 ), magnesium chloride (MgCl 2 ), acetic acid (HAc), component B is composed of sodium bicarbonate (NaHCO 3 ) or combined with sodium chloride (NaCl). Before use, the solid preparation needs to be dissolved into a solution (concentrate) with purified water according to regulations; the liquid preparation can be used directly for hemodialysis. When in use, the hemodialysis machine absorbs liquid A, liquid B and water respectively in proportion, and automatically mixes them in the machine to form a dialysate, and then performs hemodialysis on...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/14
Inventor 黎春罗建明周卫芬司徒少金
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com