Medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied in the field of compound Acanthopanax injection preparations, pharmaceutical compositions for treating cardiovascular and cerebrovascular diseases and its preparation, can solve the problems of undiscovered pharmaceutical composition reports, etc., and achieve enrichment and Easy purification, reduced amount of impurities, good stability

Inactive Publication Date: 2005-07-06
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the data retrieval, no report was found on the medicinal composition of Acanthopanax anticanax and Radix Ginseng

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Crush the stem of Acanthopanax senticosus, put it into an ultrasonic extraction tank, add 10 times the amount of water for ultrasonic oscillation extraction, the oscillation frequency is 20kHz, the time is 90 minutes, extract 4 times, control the temperature to room temperature; combine the extracts and let stand , filter, and the filtrate is concentrated under reduced pressure to a solution: the medicinal material is 1: 1, centrifuged at a speed of 12000 rpm, the centrifugate is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 5000, and the filtrate is passed through a treated polyamide column. Elute with 4 times column volume of 10% ethanol solution, and then 3 times column volume of 70% ethanol solution, collect the ethanol eluate and recover until there is no alcohol smell, concentrate, dry, and pulverize to obtain the extract of Acanthopanax senticosus .

[0100] Crush the ginseng, put it into an ultrasonic extraction tank, add 6 ti...

Embodiment 2

[0103] Crush the rhizome of Acanthopanax senticosus, put it into an ultrasonic extraction tank, add 5 times the amount of 80% ethanol solution for ultrasonic oscillation extraction, the oscillation frequency is 100kHz, the time is 20 minutes, extract twice, control the temperature to room temperature; combine the extracts , stand still, filter, and the filtrate is concentrated under reduced pressure to a solution: medicinal materials are 1: 1, centrifuged at a speed of 20,000 rpm, the centrifugate is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 10,000, and the filtrate is passed through a treated polyamide column, first eluted with 30% ethanol solution of 2 times column volume, then eluted with 40% ethanol solution of 6 times column volume, collected the ethanol eluate and recovered until it had no alcohol smell, concentrated, dried, and pulverized to obtain Acanthopanax Add extract.

[0104] Grind the garden ginseng and red ginseng, put th...

Embodiment 3

[0107] Crush the roots of Acanthopanax senticosus into an ultrasonic extraction tank, add 8 times the amount of 20% ethanol for ultrasonic oscillation extraction, the oscillation frequency is 50kHz, the time is 40 minutes, extract 3 times, control the temperature to room temperature; combine the extracts , stand still, filter, and the filtrate is concentrated under reduced pressure to a solution: medicinal materials are 1: 1, centrifuged at a speed of 18000 rpm, the centrifugate is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 6500, and the filtrate is passed through a treated polyamide column, first eluted with 3 times column volume of 20% ethanol solution, and then 4 times column volume of 60% ethanol solution, collected the ethanol eluate and recovered until it had no alcohol smell, concentrated, dried, and pulverized to obtain Acanthopanax Add extract.

[0108] Grind wild ginseng and ginseng leaves, put them into an ultrasonic extraction...

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PUM

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Abstract

Disclosed is a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, which is prepared fromacanthopanax root extract, gen-seng extract and medicinal adjuvant for water-soluble injection, and has the functions of benefiting vital energy, promoting blood circulation. The invention also discloses the process for preparing the pharmaceutical composition. Pharmacological experiment has shown that the medicinal composition has good actions for preventing and treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and specifically relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The pharmaceutical composition is also called compound Acanthopanax injection preparation. Background technique [0002] Cardiovascular and cerebrovascular diseases are clinically common and frequently-occurring diseases. In recent years, with the improvement of people's living standards, the age of onset of cardiovascular and cerebrovascular diseases has advanced. Coupled with the aging of the population structure, its incidence has been increasing year by year. The development of drugs for the treatment of cardiovascular and cerebrovascular diseases has gradually become a research hotspot. More and more clinical reports show that traditional Chinese medicine has a good application prospect in the treatment of cardiovasc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K9/19A61P9/00
Inventor 张平
Owner 张平
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