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Formulation of 'Duyiwei' with improved bioavailability and drug effect and preparation process thereof

A unique, high-availability technology, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problem of low bioavailability and achieve the effect of reducing abdominal pain

Active Publication Date: 2005-06-22
GUANGDONG LUOFUSHAN SINOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing Duyiwei preparation is a traditional hard capsule, which is full of disintegration and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Embodiment 1: the preparation of medicinal material extract:

[0095] (1). Take 1000g of the unique medicinal material, crush it into a 20-mesh coarse powder, decoct three times, 1.0 hour each time, add water for the first time to be 5 times the weight of the medicinal material, and add water for the second and third times to be 4 times the weight of the medicinal material;

[0096] (2). Combine the decoctions, filter, concentrate the filtrate to a thick paste with a relative density of 1.15 at 40°C, dry the thick paste below 100°C and grind it into a 60-mesh fine powder, which is the medicinal material for preparing dropping pills or soft capsules Extract --- dry paste powder; or from the combined decoction, filter, and the filtrate is concentrated to a thick paste with a relative density of 1.25 at 25 °C, which is also the medicinal material extract for making dropping pills or soft capsules --- thick paste;

Embodiment 2

[0097] Embodiment 2: the preparation of medicinal material extract:

[0098] (1). Take 1000g of the unique medicinal material, crush it into a 60-mesh coarse powder, decoct three times, 2.0 hours each time, the first water addition is 16 times the weight of the medicinal material, and the second and third additions are 15 times the weight of the medicinal material ;

[0099] (2). Combine the decoctions, filter, concentrate the filtrate to a thick paste with a relative density of 1.40 at 60°C, dry the thick paste below 100°C and grind it into a 200-mesh fine powder, which is the medicinal material for preparing dropping pills or soft capsules Extract --- dry paste powder; or from the combined decoction, filter, and the filtrate is concentrated to a thick paste with a relative density of 1.38 at 25 ° C, which is also the medicinal material extract for making dropping pills or soft capsules --- thick paste;

Embodiment 3

[0100] Embodiment 3: the preparation of medicinal material extract:

[0101] (1). Take 1000g of the unique medicinal material, crush it into a 40-mesh coarse powder, decoct three times, 1.5 hours each time, add water 10 times the weight of the medicinal material for the first time, and 11 times the weight of the medicinal material for the second and third times ;

[0102] (2). Combine the decoctions, filter, concentrate the filtrate to a thick paste with a relative density of 1.30 at 50°C, dry the thick paste below 100°C, and then grind it into a fine powder of 120 meshes, which is the medicinal material for preparing dropping pills or soft capsules Extract --- dry cream powder; or start from the combined decoction, filter, and the filtrate is concentrated to a thick paste with a relative density of 1.30 at 25 ° C, which is also the medicinal material extract for making dropping pills or soft capsules --- thick paste;

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PUM

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Abstract

Disclosed is a formulation of 'Duyiwei' with improved bioavailability and drug effect and preparation process thereof, which is made into the dosage forms of extract and dripping pill, each 1000 parts of medicinal material are made into dried grease or extract and dispersed medium (60-440 parts), suspension auxiliary agent (3-40 parts), surface-active agents (0.5-20 parts) so as the obtain soft capsule. The prepared capsule can be applied to the treatment of dysmenorrhoea, promoting blood circulation, and haemostasis.

Description

technical field [0001] The invention relates to a unique preparation and a preparation method for improving bioavailability and drug efficacy. Specifically, it involves a traditional Chinese medicine for the treatment of incision pain, bleeding, traumatic fractures, tendon and bone sprains, rheumatic arthralgia, metrorrhagia, dysmenorrhea, gingival swelling and bleeding after various surgical operations - Duyiwei Dropping Pills and Soft Capsules and its preparation method. technical background [0002] Duyiwei is a folk herbal medicine of Tibetan, Mongolian, Naxi and other ethnic groups, and it is the whole herb of Lamiophlomis Rotata (Benth.) Kudo, a plant of the Labiatae family. It was first recorded in the famous Tibetan medical works "Four Medical Codes" and "Yuewang Medicine Diagnosis". Modern pharmacological studies have shown that Duyiwei has hemostatic, analgesic, antibacterial, acute, and anti-tumor effects, has low toxicity, few side effects, and can also improve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61P1/02A61P7/04A61P15/00A61P19/08A61P31/04A61P35/00
Inventor 叶耀良廖志钟
Owner GUANGDONG LUOFUSHAN SINOPHARM
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