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Composite microsphere containing hydroxyapatite and preparing method thereof

A technology of hydroxyapatite and composite microspheres, applied in the field of material science, can solve the problems of low mechanical strength and brittleness, and achieve the effect of improving mechanical strength

Inactive Publication Date: 2005-03-16
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention solves the problems of low mechanical strength and brittleness of existing materials, and provides composite microspheres containing hydroxyapatite and a preparation method thereof

Method used

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  • Composite microsphere containing hydroxyapatite and preparing method thereof
  • Composite microsphere containing hydroxyapatite and preparing method thereof
  • Composite microsphere containing hydroxyapatite and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1. prepare the composite microsphere containing HA50%

[0023] 1) Weigh 0.1 g of ethyl cellulose (EC), and dissolve it in a mixed solution of 30 ml of chloroform and 30 ml of n-hexane.

[0024] 2) Dissolve 0.75g of sodium alginate (Alg) in 25ml of water, weigh 0.75g of hydroxyapatite (HA), moisten it with a small amount of water in a mortar, then pour in the sodium alginate solution, and stir while pouring It was mixed into a homogeneous white paste.

[0025] 3) Slowly pour the white paste in the mortar into the organic solution in a uniform trickle at a stirring speed of 100-200r / min, and adjust the stirrer to keep the liquid level in a funnel state. Stir for 5-15 minutes, if it is found that relatively uniform microspheres have been formed, add 25ml of 2.5% calcium chloride solution. Keep stirring at this speed for 90 minutes, then pour off the organic matter, wash with water three times, and soak in calcium chloride solution. made as figure 1 Composite...

Embodiment 2

[0026] Embodiment 2. prepare the composite microsphere containing HA70%

[0027] Weigh 0.1 g of ethyl cellulose (EC), and dissolve it in a mixture of 30 ml of chloroform and 30 ml of n-hexane.

[0028] Dissolve 0.75g of sodium alginate (Alg) in 25ml of water, weigh 1.75g ​​of hydroxyapatite (HA), moisten it in a mortar with a small amount of water, then pour the sodium alginate solution into it, and mix it while pouring into a uniform white paste.

[0029] Slowly pour the white paste in the mortar into the organic solution in a uniform trickle at a stirring speed of 100-200r / min, and adjust the stirrer to keep the liquid level in a funnel state. Stir for 5-15 minutes, if it is found that relatively uniform microspheres have been formed, add 25ml of 2.5% calcium chloride solution. Keep stirring at this speed for 90 minutes, then pour off the organic matter, wash with water three times, and soak in calcium chloride solution. made as figure 2 Composite microspheres containin...

Embodiment 3

[0030] Example 3. Preparation of gelatin-containing hydroxyapatite / alginate composite microspheres

[0031] Weigh 0.1 g of ethyl cellulose (EC), and dissolve it in a mixture of 30 ml of chloroform and 30 ml of n-hexane.

[0032] Dissolve 0.75g of sodium alginate (Alg) and 0.25g of gelatin in 25ml of water, weigh 1.75g ​​of hydroxyapatite (HA), moisten it in a mortar with a small amount of water, then pour in the sodium alginate solution, and pour Whisk to combine into a homogeneous white paste.

[0033] Slowly pour the white paste in the mortar into the organic solution in a uniform trickle under stirring, and adjust the agitator to keep the liquid level in the funnel state. Stir for a period of time, if it is found that relatively uniform microspheres have been formed, add 25ml of 2.5% calcium chloride solution. Keep stirring at this speed for 90 minutes, then pour off the organic matter, wash with water three times, and soak in calcium chloride solution. made as image 3...

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Abstract

The invention provides a composite microsphere containing hydroxyapatite and preparing method thereof, wherein the weight percentage of its constituents include sodium alginate 20-50%, hydroxyapatite 40-70%, gelatin 0-13%, acacia gum 0-13%, the preparing process consists of formulating organic phase, charging the microsphere into the organic phase, agitating, charging calcium chloride solution, washing with water, immersing in water or 2.5% of calcium chloride solution for storage.

Description

technical field [0001] The invention belongs to the technical field of material science, and in particular relates to a composite microsphere containing hydroxyapatite and a preparation method thereof. Background technique [0002] Hydroxyapatite is one of the most researched bioactive materials at present. It is widely used in various bone repair materials, cells and drug carriers, and it is also used in inhibiting cancer cells. However, hydroxyapatite itself is very brittle, difficult to form, and slightly soluble in water. There are few literature reports on hydroxyapatite microspheres, which largely limits its application. [0003] Alginate is a kind of natural polysaccharide polymer, which is non-toxic and biodegradable. Sodium alginate has attracted much attention because of its gelation in the presence of multivalent cations, and has been widely used in food, cosmetics, and biomedicine. a wide range of applications. Alginate microcap...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/632
Inventor 成国祥刘超赵孔银张风菊
Owner TIANJIN UNIV
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