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Preparation method of therapy used iodine-125 sealed seed source core

A technology for sealing the seed source and the source core, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, radioactive physical shapes, etc., can solve the problems of generating a large amount of oxygen, difficult cleaning operations of silver chloride rods, etc., to reduce decomposition, Overcome the effects of compactness and firmness, and reduce the effect of pollution

Inactive Publication Date: 2005-03-16
天津赛德生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of this method is that a large amount of oxygen is produced during the chlorination reaction, which brings certain difficulties to the cleaning operation of silver chloride rods.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Wash 100 silver rods (φ0.5×3mm) with acetone, put them into a reaction bottle, add 1mL 10mg / mL potassium ferricyanide solution, add 4mL 2mol / L sodium chloride aqueous solution, mix well, shake After reacting for 5 hours, a layer of dense silver chloride precipitation was formed on the surface of the silver rod, and the silver rod was taken out, washed three times with deionized water, and dried for later use;

[0025] (2) In the reaction bottle, first add 0.2mL 10mg / mL sodium iodide solution and 0.2mL 20mg / mL sodium bromide solution, then add 100 chlorinated silver rods, add 100mCi radioactive sodium iodide solution, and use Adjust the pH to 10 with 0.01mol / L NaOH solution, mix evenly, shake and react for 9 hours, and then obtain the iodine-125 sealed seed source source core for treatment.

[0026] The utilization rate of iodine-125 is greater than 98%.

[0027] Utilization rate of iodine-125 = (activity of iodine-125 input - activity of iodine-125 in the solution ...

Embodiment 2

[0030] (1) Wash 100 silver rods (φ0.1×3mm) with acetone, put them into a reaction bottle, add 12mL 1mg / mL potassium ferricyanide solution, add 1mL 6mol / L sodium chloride aqueous solution, mix well, shake After reacting for 8 hours, a layer of dense silver chloride precipitation was formed on the surface of the silver rod, and the silver rod was taken out, washed twice with deionized water, and dried for later use;

[0031] (2) In the reaction bottle, first add 0.05mL 100mg / mL sodium iodide solution and 0.05mL 150mg / mL sodium bromide solution, then add 100 chlorinated silver rods, add 200mCi radioactive sodium iodide solution, and use Adjust the pH to 8 with 0.01mol / L NaOH solution, mix evenly, shake and react for 10 hours, and then obtain the iodine-125 sealed seed source source core for treatment.

Embodiment 3

[0033] (1) Wash 100 silver rods (φ0.7×3.5mm) with acetone, put them into a reaction bottle, add 0.0mL 100mg / mL potassium ferricyanide solution, add 10mL 0.1mol / L potassium chloride aqueous solution, mix Evenly, shake and react for 3 hours, forming a layer of dense silver chloride precipitation on the surface of the silver rod, take out the silver rod, wash it twice with deionized water, and dry it for later use;

[0034] (2) In the reaction flask, first add 17mL 1mg / mL potassium iodide solution and 17mL 1mg / mL potassium bromide solution, then add 100 chlorinated silver rods, add 10mCi radioactive sodium iodide solution, and use 0.01mol / L NaOH Adjust the pH of the solution to 9, mix evenly, shake and react for 8 hours, and then obtain the iodine-125 sealed seed source source core for treatment.

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Abstract

The invention discloses a preparation method of therapy used iodine-125 sealed seed source core which comprises the steps of, (1) charging silver rod, potassium ferricyanide aqueous solution and soluble alkali metal chloride aqueous solution into reaction container, oscillating reaction for 3-8 hours, taking-up chlorination silver rod, rinsing with deionized water 1-3 times, airing, (2) charging alkali metal chloride iodide aqueous solution, alkali metal chloride bromide aqueous solution, chlorination silver rod and radioactive sodium iodide aqueous solution into reactor at pH=8-10, oscillating reaction for 8-10 hours.

Description

technical field [0001] The invention belongs to the preparation method of medical radioactive sealed seed source core, in particular, relates to a preparation method of radioactive sealed seed source core for tumor implantation treatment. Background technique [0002] Interstitial implantation therapy is to implant radioactive seeds into the tumor or around the tumor, and use the rays emitted by the seeds to kill cancer cells, so as to achieve the purpose of treating and alleviating the disease. Interstitial implant therapy has been used in the treatment of various solid tumors, such as prostate cancer, breast cancer, liver cancer, brain tumor and ovarian cancer, and has achieved the same therapeutic effect as surgery and external radiation therapy. Interstitial implantation is divided into temporary implantation and permanent implantation. Permanent implantation refers to implanting the radioactive seed source into the tumor site without taking it out, while temporary impla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/00A61K51/02A61K51/12
Inventor 阎尔坤
Owner 天津赛德生物制药有限公司
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