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Cefixime pharmaceutical composition for injection

A drug compound, cefixime technology, applied in the directions of drug delivery, antibacterial drugs, pharmaceutical formulations, etc., can solve the problems of cefixime cannot be directly made into injections, low bioavailability of oral preparations, and gastrointestinal adverse reactions. , to achieve the effect of low cost, low toxicity, and reduced toxic and side effects

Inactive Publication Date: 2005-03-16
余安国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problem that cefixime cannot be directly made into injection, its oral preparation has low bioavailability, and there are a series of gastrointestinal adverse reactions, and provides a cefixime preparation that can be used for injection, which can fully exert the The antibacterial effect of cefixime overcomes the defects caused by oral preparations of cefixime

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: preparation example

[0021] prescription:

[0022] Raw material name dosage

[0023] Cefixime 100g

[0024] L-Arginine 100g

[0025] Make 1000 pieces

[0026] Preparation Process:

[0027] Under a sterile environment, fully mix 100 g of cefixime refined product (refined with methanol, aseptically washed and dried with 75% ethanol) and 100 g of L-arginine sterile powder in a sterile aluminum bucket, and pack into Pack of 1000, closed with butyl rubber stoppers.

Embodiment 2

[0028] Embodiment 2: preparation example

[0029] prescription:

[0030] Raw material name dosage

[0031] Cefixime 100g

[0032] Anhydrous sodium carbonate 33.3g

[0033] Make 1000 pieces

[0034] Preparation Process:

[0035] Under a sterile environment, 100 g of cefixime refined product (refined with methanol, aseptically washed with 75% ethanol, and dried) and 33.3 g of anhydrous sodium carbonate sterile powder are fully mixed in a sterile aluminum bucket, and packed into Pack of 1000, closed with butyl rubber stoppers.

Embodiment 3

[0037] weight ratio

[0038] It can be seen from the above table that the cefixime complex prepared by cefixime and L-arginine at a weight ratio of 1.5:1 has good solubility in water, and the pH value is moderate, and the relevant substances are qualified.

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PUM

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Abstract

The invention discloses a cefixime pharmaceutical composition for injection, which is prepared from active component cefixime and solubility promoter by the weight proportion of 1-15 : 1 thus fully mixing in asepsis environment, the solubility promoter is selected from alkaline amino acids, alkali metals, or the inorganic or organic acid salt of alkaline-earth metals.

Description

Technical field: [0001] The invention relates to a drug compound of cephalosporin antibiotics, in particular to the third-generation cephalosporin antibiotic cefixime as an active ingredient, basic amino acids, inorganic or organic acid salts of alkali metals or alkaline earth metals as auxiliary components. Solvent, prepared drug compound for injection. Background technique: [0002] The antibiotic cefixime (Cefixime, C 16 h 15 N 5 o 7 S 2 ) is a third-generation oral cephalosporin antibiotic. Cefixime has a strong affinity for target enzymes and high stability for β-lactamase. Cefixime has a broad-spectrum antibacterial effect on Gram-positive and Gram-negative bacteria, especially influenzae (such as: Streptococcus pneumoniae, Streptococcus epidermidis), pneumococcus and Gram-negative bacteria among Gram-positive bacteria Haemophilus influenzae, Moraxella, Catarella, Proteus mirabilis, Neisseria gonorrhoeae, Branhamella catarrhalis, Escherichia coli, Klebsiella, Se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/546A61P31/04
Inventor 余安国林国华唐朝云莫兆明李莎
Owner 余安国
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