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Preparation method of quantum point microspheric for bio-medical fluorescence probe

A fluorescent probe, biomedical technology, used in biological testing, fluorescence/phosphorescence, material testing, etc., to achieve the effects of controllable particle size, high efficiency and low cost of microspheres

Inactive Publication Date: 2005-01-05
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of the microspheres and the filling of the quantum dots are carried out step by step. When filling the quantum dots of different fluorescent colors into the microspheres, the quantum dots must be added in order, and the quantum dots enter the holes in the microspheres. need some time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of polyacrylonitrile quantum dot microspheres with single fluorescent color (inlet temperature is 180°C)

[0029] Mix and dissolve acrylonitrile, methyl acrylate and azobisisobutyronitrile, then add polyvinyl alcohol and deionized water, and carry out stirring reaction at 60°C, filter, wash and dry the reaction product polyacrylonitrile.

[0030] The obtained polyacrylonitrile is dissolved in N,N-dimethylformamide solution, and the quantum dot CdSe nanoparticle that has the maximum luminescence at 630nm and the full width at half maximum of its spectrum is 40nm is added, and the quantum dot is oscillated until the quantum dot is in the polypropylene Uniformly dispersed in the nitrile solution, and then under the protection of nitrogen at a feed rate of 3mL·S -1 , The air inlet temperature is 180°C, and the rotation speed of the atomizing disc is 3000r·min -1 conditions for spray drying. Obtain spherical particles with a particle size of less tha...

Embodiment 2

[0031] Example 2: Preparation of polyacrylonitrile quantum dot microspheres with single fluorescent color (inlet temperature is 250°C)

[0032] Dissolve polyacrylonitrile in N,N-dimethylformamide solution, add quantum dot CdSe nanoparticles that have maximum luminescence at 630nm and have a spectral half-maximum width of 40nm, and oscillate until the quantum dots are in the polyacrylonitrile solution uniformly dispersed in the medium, and then under the protection of nitrogen at a feed rate of 3mL·S -1 , The air inlet temperature is 250°C, and the rotation speed of the atomizing disc is 3000r·min -1 conditions for spray drying. Spherical particles with a particle size of less than 5 microns are obtained, that is, quantum dot microspheres. There are also some filaments in the product. By changing the ratio of a quantum dot to polyacrylonitrile, a quantum dot microsphere with a new luminous intensity can be obtained, and the half-height width of the fluorescence spectrum of t...

Embodiment 3

[0033] Example 3: Preparation of polyacrylonitrile quantum dot microspheres with multiple fluorescence spectra

[0034] The preparation method of polyacrylonitrile is identical with embodiment 1.

[0035]The obtained polyacrylonitrile is dissolved in N,N-dimethylformamide solution, and the quantum dot CdSe nanoparticles with maximum luminescence at 520nm, 570nm and 630nm and half maximum width of 40nm are added respectively. The concentration ratio of the dots was 1:1:1, 1:0:1, 1:1:3, 2:3:5, 2:5:10, and the mixed solution was oscillated until the quantum dots in the polyacrylonitrile solution reached Uniformly disperse, and then under nitrogen protection at a feed rate of 3mL·S -1 , The air inlet temperature is 180°C, and the rotation speed of the atomizing disc is 3000r·min -1 The mixed solution of quantum dots and polyacrylonitrile was spray-dried under the conditions. Spherical particles with a particle size of less than 10 microns are obtained, that is, quantum dot micr...

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Abstract

The invention is a manufacturing method for quanta point microsphere used as biomedicine fluorescence probe. It belongs to chemical engineering, material and biomedicine field. The invention uses spray and drying method to embeds the quanta point into high molecular material, forms quanta microsphere with particle distribution less than 10 micrometers, the quanta point nanometer particle with different quantity and different fluorescence character is dispersed in the high molecular liquid, then carries on spray and drying, it changes the fluorescence character of the microsphere through changing type of quanta point material, quantity of the quanta point and the color and intensity of the quanta point, controls the particle size and figure of the quanta microsphere through adjusting the condition of spray and drying.

Description

technical field [0001] The invention relates to a preparation method of a biomedical quantum dot microsphere, in particular to a preparation method of a quantum dot microsphere used as a biomedical fluorescent probe. It belongs to the intersection field of chemical engineering, materials and biomedical technology. Background technique [0002] Quantum dots refer to semiconductor nanocrystals, nanoparticles mainly composed of II-VI cluster or III-IV cluster elements. Due to the small size of the crystal grain, its electrons and holes are quantum-confined, there are discontinuous highest occupied molecular orbitals and lowest unoccupied orbital energy levels, and the energy gap widens. Under the excitation of light, it can emit fluorescence. It has traditional fluorescent substances. Incomparable and unique optical properties. [0003] In recent years, some well-known international journals have continuously reported the application research of quantum dots in biomedicine. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64G01N33/52
Inventor 储茂泉徐宇虹
Owner SHANGHAI JIAO TONG UNIV
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