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Process for extracting water grind thisvine using alcohole as single organic dissolvent

A technology of organic solvents and silymarin, which is applied in organic chemistry and other fields, and can solve problems such as solvent residues

Inactive Publication Date: 2005-01-05
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction process of the present invention only uses ethanol as a single organic solvent, adopts a gradient method process, and solves the problem of solvent residue in silymarin

Method used

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  • Process for extracting water grind thisvine using alcohole as single organic dissolvent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: first squeeze milk thistle seed into the oil cake that thickness is 1.5mm, pulverize into 20 meshes and sieve, carry out reflux extraction with 85% ethanol of 4 times the amount of oil cake, extract altogether four times, then after the extract is concentrated , cooled to 30 degrees Celsius, and then separated to remove the upper part of the milk thistle oil, the lower part of the precipitated solid matter was added to 3 times the amount of deionized water, heated and stirred to 80 degrees Celsius, kept for 30 minutes, then poured out the upper layer of liquid, and the lower part of the solid Add 3 times the amount of 15% ethanol to the substance, heat and keep it under reflux for 1 hour, then pour out the upper layer of liquid, and then use water for the lower solid to do the aforementioned treatment, and then use the aforementioned ethanol treatment method. Add 0.1%-2% (mass percentage concentration) of edible sodium carbonate solution 3 times, keep at 70...

Embodiment 2

[0021] Embodiment 2: first squeeze milk thistle seed into the oil cake that thickness is 2mm, pulverize 20 meshes and sieve, carry out reflux extraction with 3 times the amount of 90% ethanol, extract altogether three times, then after the extract is concentrated, cool to 35 Celsius, then separate and remove the milk thistle oil in the upper part, add 5 times the amount of deionized water to the solid matter precipitated in the lower part, heat and stir to 85 degrees Celsius, keep for 30 minutes, then pour out the upper liquid, add 3 Double the amount of 25% ethanol, heat and keep reflux for 40 minutes, then pour out the upper layer liquid, and then use water for the lower solid matter to do the aforementioned treatment, add 0.1%-2% (mass percentage concentration) edible sodium carbonate solution in the gained solid matter 4 times, keep at 75 degrees Celsius for 40 minutes, then pour out the upper liquid, and then use water to treat the lower solids, then use the aforementioned...

Embodiment 3

[0022] Embodiment 3: first squeeze milk thistle seed into the oil cake that thickness is 2.5mm, pulverize 20 meshes and sieve, carry out reflux extraction with 4 times the amount of 95% ethanol, extract altogether four times, then after the extract is concentrated, cool to 30 degrees Celsius, then separate and remove the milk thistle oil in the upper part, add 4 times the amount of deionized water to the solid matter precipitated in the lower part, heat and stir to 90 degrees Celsius, keep for 20 minutes, then pour out the upper layer of liquid, in the lower part of the solid matter Add 2.5 times the amount of 25% ethanol, heat and maintain reflux for 30 minutes, then pour out the upper layer of liquid, and then use water for the lower solids to do the aforementioned treatment, and add 0.1%-2% (mass percentage concentration) of edible carbonic acid to the resulting solids 3 times the sodium solution, keep it at 80 degrees Celsius for 30 minutes, then pour out the upper liquid, ...

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Abstract

The invention discloses a process of extracting silymarine by using alcohol as a single organic solvent, adopting edible alcohol to extract silymarine, then adopting alcohol and water to wash twice so as to eliminate oil and impurities, using edible sodium carbonate for elution, drying the silymarine solids obtained by fulling and then crushing and obtaining the final product, where by the UV determination, the total flavone content in the silymarine has mass percent concentration of 70%-90%, the product yield is 2-3% of the quantity of silymarine seeds from which the oil has been extracted. It solves the problem of harmful solvent residues in current silymarine products, and it can obtain the silymarine products without harmful solvent residues.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a silymarin extraction process using ethanol as a single organic solvent for separating and extracting monomeric medicines from natural product Chinese herbal medicines. Background technique [0002] Silymarin is a general term for flavonoids extracted from the seeds of the natural product milk thistle, mainly including 5 flavonoids such as silybin and isosilibin. Silymarin has significant antioxidant and free radical scavenging effects, and is currently mainly used in the treatment of liver diseases. Secondly, silymarin also has significant curative effects on some diseases of the cardiovascular system such as hyperlipidemia. [0003] The extraction of silymarin was usually carried out with ethyl acetate in the early stage. At present, silymarin is mostly extracted from milk thistle seeds with acetone, and then degreased with petroleum ether or hexane to obtain yellow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/28
Inventor 杜永峰
Owner XIAN UNIV OF TECH
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