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Method for preparing Baicalin prepn. for external use

A preparation method and technology of baicalin, applied in the field of preparation of external baicalin preparations, to achieve the effect of reducing tissue ischemia-reperfusion injury, good clinical development and application value, and low toxicity

Inactive Publication Date: 2005-01-05
张喜平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Baicalin (glycoside) is a flavonoid compound. At present, there is no baicalin (glycoside) solution officially approved by the State Food and Drug Administration for clinical use, and baicalin (glycoside) has many pharmacological activities. It is effective in scavenging oxygen free radicals. , reduce tissue ischemia-reperfusion injury, regulate immune function, protect liver and gallbladder, anti-infection, anti-tumor and other aspects have certain effects. The composition of baicalin (glucoside) has good solubility, low toxicity, and has good clinical development and application value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Formula of 20% baicalin (glycoside) liquid: weigh 1010 grams (5000ml*20% / 99%) of baicalin (glycoside) powder with a purity > 95% (such as 99%) and antioxidants according to the required volume of 5000ml : Sodium thiosulfate (add 0.05-0.2g per 100ml), add water for injection to 65-85% of the pre-proportioned volume of 5000ml, adjust the pH to 5.5-8.0 with 5%-20% NaOH solution, and use 1% if necessary -10% HCL for adjustment, or add 0.1%-10% co-solvent polyethylene glycol at the same time to increase its stability. Add water to make up the volume according to 20% concentration and let it stand for more than one day, that is, 5000 milliliters contains 1010 grams of baicalin, and the osmotic pressure is qualified. Then filter with filter paper, vertical melting funnel, and 0.22um microporous membrane in turn, pack them in glass containers, and sterilize at 115°C for 30 minutes. It can be obtained after passing the pyrogen, vascular fragility and sterility tests. When i...

Embodiment 2

[0045] 20% baicalin (glycoside) ointment formula:

[0046] 1) Take the baicalin (glucoside) powder after the sterilization according to the required weight of 5000 grams, such as weighing 1010 grams of baicalin (glycoside) powder with a purity > 95% (such as 99%) (5000 grams * 20% / 99%), add an appropriate amount of medical alcohol and stir into a thin paste.

[0047] 2) Add about 80% of the required weight of Vaseline to make a paste. If necessary, add an appropriate amount of zinc oxide powder (equivalent to 0.5%--10% of the required weight), and then put it into containers and store it in a cool place for later use. It is obtained after the skin allergy test is confirmed by animal experiments.

[0048] 3) When using, apply baicalin (glycoside) ointment directly to the affected area, with or without a cleansing dressing depending on the specific situation. It can be used externally to treat infected incisions, ulcers, abscesses, furuncles, carbuncles, burn wounds, sinuses, e...

Embodiment 3

[0050] Another 20% baicalin (glycoside) ointment formula:

[0051] 1) Take the baicalin (glucoside) powder after the sterilization according to the required weight of 5000 grams, such as weighing 1010 grams of baicalin (glycoside) powder with a purity > 95% (such as 99%) (5000 grams * 20% / 99%), add an appropriate amount of medical alcohol and stir into a thin paste. Add about 80% of the required weight of commercially available cream to make a paste, if necessary, add an appropriate amount of zinc oxide powder (equivalent to 0.5%--10% of the required weight), after animal experiments confirm that its skin allergy test is qualified Instantly.

[0052] 2) When using, apply baicalin (glycoside) ointment directly to the affected area, with or without a cleansing dressing according to specific conditions. It can be used externally to treat infected incisions, ulcers, abscesses, furuncles, carbuncles, burn wounds, sinuses, etc.

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PUM

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Abstract

An exterior-applied baicalin medicine in the form of liquid or ointment is prepared from baicalin powder through proportionally mixing it with the water for injection, regulating pH=5.5-8.0, laying aside for at least one day, and filter to obtain liquid, or proportionally mixing it with medical alcohol, stirring, adding vaseline and stirring to obtain ointment. It can regulate immunity, protect liver and gallbladder, and treat infection and tumor.

Description

technical field [0001] The invention relates to a preparation method, in particular to a preparation method of external baicalin preparation. Background technique [0002] Baicalin (glycoside) is a flavonoid compound. At present, there is no baicalin (glycoside) solution officially approved by the State Food and Drug Administration for clinical use, and baicalin (glycoside) has many pharmacological activities. It is effective in scavenging oxygen free radicals. , reduce tissue ischemia-reperfusion injury, regulate immune function, protect liver and gallbladder, anti-infection, anti-tumor and other aspects have certain effects. The composition of baicalin (glycoside) has good solubility and low toxicity, and has good clinical development and application value. Contents of the invention [0003] The present invention aims to solve the above-mentioned deficiencies, and provides a preparation method of baicalin preparation for external use. [0004] The technical solution ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/7048A61P1/16A61P31/00A61P35/00A61P37/02
Inventor 张喜平
Owner 张喜平
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