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Use of Abidol in preparing medicines for treating and preventing SARS virus

A technology of SARS virus and Arbidol, which is applied in the application field of preparing medicines for preventing and treating SARS virus, can solve the problems of common cold, no specific treatment and prevention means, etc.

Inactive Publication Date: 2004-12-08
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Human coronaviruses belong to two antigen types, OC43 and 229E, respectively. They are pathogens that cause upper respiratory tract infections in humans, and often cause common colds in adults. There is no specific treatment and prevention method.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, Arbidol hydrochloride in vitro anti-SARS virus preliminary screening test

[0020] 1. Experimental materials:

[0021] 1. Drugs: Arbidol hydrochloride raw materials

[0022] 2. Cells: African green monkey kidney cells (Vero E6), provided by the virus room cell bank of the Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences

[0023] 3. Virus: SARS virus, BJ-01 strain, provided by the virus room of the Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences

[0024] 4. Medium: DMEM medium plus 10% calf serum

[0025] 2. Basic conditions of the test: Viruses are tested in a biosafety level 3 laboratory.

[0026] 3. Determination of virus virulence:

[0027] Vero E6 cells were seeded in a 96-well plate, 100 μl per well, containing 2×10 cells 4 , 37□ cultured for 24h, the cells grew into a single layer, added 10-fold diluted virus medium with 9 concentrations, 37□, 5% CO 2 Incubator culture, every day ...

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PUM

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Abstract

An application of Abiduoer in preparing the medicines for preventing and treating SARS is disclosed.

Description

technical field [0001] The present invention relates to the new medicinal use of Arbidol, in particular to the application of the compound in the preparation of drugs for the prevention and treatment of SARS virus. Background technique [0002] As far as is known, the Coronaviridae family only infects vertebrates and is associated with many diseases in humans and animals. Human coronaviruses belong to two antigen types, OC43 and 229E, respectively. They are pathogens that cause upper respiratory tract infections in humans, and often cause common colds in adults. There is no specific treatment and prevention method. The full name of SARS is Severe Acute Respiratory Syndrome, which is related to a new coronavirus that has never been found in humans or animals. [0003] Arbidol hydrochloride is a new non-nucleoside antiviral drug. It is a highly effective drug for preventing and treating influenza A and B and other acute respiratory virus infections. By a...

Claims

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Application Information

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IPC IPC(8): A61K31/405A61P11/00A61P31/14
Inventor 李建青张宏武刘超王荣端申东民李银贵
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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