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Method for extracting neohesperidin from young fruits of citrus aurantium

A technology of neohesperidin and plant acid, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of limited resources, difficulty in collecting fresh sweet orange peel, and low yield, and achieve the goal of preparing The effect of simple process

Active Publication Date: 2004-11-17
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fresh sweet orange peel is difficult to collect, resources are limited, and the yield of neohesperidin extracted from fresh sweet orange peel is also low

Method used

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  • Method for extracting neohesperidin from young fruits of citrus aurantium
  • Method for extracting neohesperidin from young fruits of citrus aurantium
  • Method for extracting neohesperidin from young fruits of citrus aurantium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 1 kg of crude drug, add 8 liters of water, decoct for 2 hours, filter, extract 2 times of medicinal residues according to the above method, combine 3 times of water extracts, concentrate under reduced pressure until the weight of the concentrated solution is 1 kg, add 95% ethanol Make the alcohol content reach 75%, stir, stand still for 24 hours, filter the supernatant, concentrate the supernatant under reduced pressure until the weight of the concentrate is 2 kg, then extract the concentrate 5 times with water-saturated n-butanol, each time The amount of n-butanol used was 800 ml; the n-butanol extracts were combined, filtered, and 2000 ml of butanol was recovered by distillation under reduced pressure. The n-butanol concentrate was cooled and crystallized for 2 days, and the crystals were collected by filtration to obtain 198 grams of neohesperidin mixture.

[0022] The above neohesperidin mixture was dissolved in 800 ml of 90% ethanol, heated and refluxed at nor...

Embodiment 2

[0025] Put 250 kg of crude drug and 2000 liters of water into the extraction pot, decoct for 2 hours, then release the water extract, add 2000 liters of water to the crude drug residue, extract 2 times according to the above method, and concentrate the water extract 3 times under reduced pressure to the concentration of the concentrate. The weight is about 250 kg, add 95% ethanol to make the alcohol content reach 70%, fully stir, let stand for 24 hours, filter the supernatant, concentrate under reduced pressure until the weight of the concentrated solution is 500 kg, and then use saturated n-butane Alcohol extraction concentrated solution 5 times, each n-butanol consumption is 240 liters; Combine n-butanol extracts, filter, and recover butanol by vacuum distillation to about 600 liters of butanol concentrates, then cool and analyze the n-butanol concentrates After 2 days of crystallization, the crystals were collected by filtration to obtain 52.0 kg of neohesperidin mixture.

...

Embodiment 3

[0029] The limes are collected, dried and crushed into a coarse powder for later use.

[0030] Weigh 1 kg of crude drug, add 8 liters of methanol, heat and reflux for 2 hours, filter, extract the medicinal residue twice according to the above method, combine the methanol extracts for 3 times, recover methanol, make the weight of the concentrated solution 2 kg, and then use n-butyl Extract the concentrated solution with alcohol 5 times, and use 800 ml of n-butanol each time; combine the n-butanol extracts, filter, recover 2000 ml of n-butanol, and filter the n-butanol concentrate to obtain 202.4 grams of neohesperidin mixture.

[0031] The above neohesperidin mixture was dissolved in 800 ml of 90% ethanol, heated to reflux for 2.5 hours, refrigerated and filtered, and the crystals were collected by filtration to obtain 103.3 grams of crude neohesperidin.

[0032] Add 10000 ml of water to 103.3 grams of crude neohesperidin, recrystallize, filter the crystals, wash with water, drai...

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Abstract

The invention relates to a method for extracting NHDC from the young fruits of Rutaceae plants acid oranges, which comprises, using water-extraction-alcohol-deposition method or alcohol-extraction to abstract the total extractive, extrcting the total extractive with n-butylalcohol to obtain the NHCD mixture, subjecting the mixture to ethanol backflow, recrystallization with water to obtain the high purity NHCD.

Description

technical field [0001] The invention relates to a preparation method of a dihydroflavonoid compound "neohesperidin", in particular to a method for extracting neohesperidin from the young fruit of the Rutaceae plant lime. Background technique [0002] Neohesperidin belongs to dihydroflavonoids in flavonoids, its molecular formula is C28H34O15, and its molecular weight is 610.57. [0003] The structural formula is: [0004] [0005] Because of its complex structure, total synthesis is difficult, and now it is generally prepared by chemical reaction conversion of naringin extracted from plants to prepare neohesperidin. [0006] Neohesperidin is the precursor of neohesperidin dihydrochalcone. As long as it is hydrogenated and reduced, it can generate the sweetener neohesperidin dihydrochalcone. This sweetener is widely used in medicine, Food and beverage and other fields, is a very valuable compound. [0007] In the document "Spectrum Analysis of Neohesperidin Structure", ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H17/07
Inventor 肖乐扩林英昌
Owner GUANGZHOU HANFANG PHARMA
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