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Houttuynin sodium powder injection and its prepn

A new technology of Houttuyfonate Sodium and Herbaceous Sodium Powder Injection, which is applied to anti-inflammatory agents, powder delivery, antiviral agents, etc., to achieve the effects of easy long-term storage, simple preparation method, and easy control

Inactive Publication Date: 2004-09-08
YANGPU HG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a new houttuyfonate sodium formulation that can be stored for a long time without degradation or other chemical changes, thereby fundamentally solving the problem of the stability of the new houttuyfonate sodium

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The following preparation method steps are adopted to prepare the new houttuyfonate sodium powder injection preparation of the following formula:

[0030] (1) Weigh 2g of Houttuyfonate Sodium and 25g of Tween-80, add a small amount of water for injection, and stir to fully wet Houttuyfondin Sodium;

[0031] (2) Add water for injection with a formula amount of 30% (300 milliliters), and fully stir to dissolve neohouttuyfonate sodium;

[0032] (3) Add 50g of mannitol, stir to make it dissolve, then add water for injection with a formula volume of 60% (600 milliliters) and mix;

[0033] (4) Add 0.01% activated carbon, boil for 5 minutes, and decarbonize by filtering with a 0.22 μm filter membrane;

[0034] (5) freeze-drying to obtain a freeze-dried powder;

[0035] (6) Adjust the filling volume of the above-mentioned freeze-dried powder and carry out sub-packaging.

[0036] The formula of this embodiment is:

[0037] New Houttuyniatin Sodium 2g

[0038] Tween-80 25g ...

Embodiment 2

[0042] The following preparation method steps are adopted to prepare the new houttuyfonate sodium powder injection preparation of the following formula:

[0043](1) Take 1g of Houttuyfonate Sodium and 15g of Tween-80, add a small amount of water for injection, and stir to fully wet Houttuyfondin Sodium;

[0044] (2) Add water for injection of 30% (300 milliliters) of the formula, fully stir, and dissolve main new houttuyfonate sodium;

[0045] (3) Add 38g of mannitol, stir to make it dissolve, then add water for injection with a formula volume of 60% (600 milliliters) and mix;

[0046] (4) Add 0.02% activated carbon, boil for 2 minutes, filter and decarbonize with a 0.22 μm filter membrane, add water for injection to the filtrate to the full amount, that is, add water for injection to 1000 ml;

[0047] (5) The above-mentioned filtrate is subpackaged in vials under aseptic conditions, and a ventilated rubber stopper is added;

[0048] (6) freeze-drying to obtain new houttuyfo...

Embodiment 3

[0055] Adopt the method substantially identical with embodiment 2 to prepare, just the add-on of step (4) gac is 0.005%, boiling time is 10 minutes, and the freeze-drying of step (6) is carried out under vacuum condition. The formula used in this embodiment is:

[0056] New Houttuyniatin Sodium 7g

[0057] Tween-80 54g

[0058] Mannitol 73g

[0059] Add water for injection to 1000ml

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Abstract

The present invention relates to one kind of houttuynin sodium powder for injection and its preparation. The houttuynin sodium powder for injection contains houttuynin sodium in 1-10 wt%, solubilizer in 20-40 wt% and excipient in 50-70 wt%. The houttuynin sodium powder for injection may be stored for long term without degradation and other chemical change, and the present invention solves the problem of houttuynin sodium in shelf stability.

Description

technical field [0001] The invention relates to a novel houttuyfonate sodium powder injection preparation and a preparation method thereof. Background technique [0002] Houttuyniatin is the antibacterial active ingredient in the traditional Chinese medicine Houttuynia cordata, and its chemical name is decanoyl acetaldehyde. It has antibacterial, analgesic, anti-inflammatory, antiviral, hemostatic, cough relieving, promoting tissue regeneration, dilating capillaries, increasing blood flow, enhancing immunity and other effects. Its anti-inflammatory effect is used to treat upper respiratory tract infection, chronic bronchitis, pneumonia, whooping cough, and various gynecological inflammations such as annex inflammation, pelvic inflammatory disease, chronic cervicitis, etc. It also has certain curative effect on acute conjunctivitis, urinary tract infection, etc.; The virus effect is manifested in the inhibition of influenza virus and hepatitis B virus. [0003] However, due...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/255A61P11/00A61P13/02A61P15/00A61P29/00A61P31/04A61P31/12
Inventor 郭德
Owner YANGPU HG PHARMA
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