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Double layer slow release preparation for nitrendipine

A double-layer dipine and nitrendipine technology is applied in pill delivery, medical preparations containing active ingredients, cardiovascular system diseases, etc., and can solve problems such as inability to achieve rapid blood pressure reduction and slow onset of action

Inactive Publication Date: 2004-09-01
王颖 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simple sustained-release preparations have a slow onset of action and cannot achieve the purpose of rapid blood pressure reduction

Method used

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  • Double layer slow release preparation for nitrendipine
  • Double layer slow release preparation for nitrendipine

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment

[0016] Specific examples, drug preparation

[0017] Nitrendipine sustained-release drug (part)

[0018] Nitrendipine 25mg Lactose 10mg

[0019] Hydroxypropyl Methyl Cellulose 50mg Ethyl Cellulose 5mg

[0020] Magnesium stearate 1% (dry granule weight)

[0021] Appropriate amount of 1.5% hydroxypropyl methylcellulose solution

[0022] Nitrendipine immediate release drug (part)

[0023] Nitrendipine 5mg Lactose 40mg

[0024] Starch 15mg Sodium hydroxymethyl starch 5mg

[0025] Magnesium stearate 1% (dry granule weight)

[0026] Appropriate amount of 8% polyvinylpyrrolidone solution.

[0027] Preparation: dry, pulverize and pass through a 100-mesh sieve for the raw materials required for the above preparation.

[0028] Wherein the sustained-release drug part raw material preparation: according to the above, the prepared nitrendipine, lactose, ethyl cellulose and hydroxypropyl methyl cellulose were pulverized through a 40-mesh sieve and mixed uniformly. Add an appropriate...

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PUM

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Abstract

The invention relates to a double layer slow release preparation for containing Nitrendipine, wherein the Nitrendipine double layer tablet can be prepared by double layer tablet compressing machine, or in the form of tablet using slow release medicament as core, or quick release medicament as outer layer clothing sheet, or in the form of capsule comprising quick release and slow release microcapsule and micro-balloons, or other preparation formed comprising the two portions of quick release and slow release medicament, wherein the weight ratio of the quick release medicament and slow release medicament is from 1:1 to 1:10, the advantages of the preparation are quick effect, long maintaining time, ideal hypertension effect and low price.

Description

technical field [0001] The present invention relates to a double-layer sustained-release preparation containing nitrendipine. Background technique [0002] Nitrendipine (nitrendipine) is a second-generation calcium antagonist developed in the 1980s. It is a calcium antagonist that selectively acts on vascular smooth muscle. It has a better selection effect on coronary robbery veins. It can reduce myocardial oxygen consumption and has a protective effect on ischemic myocardium; it can reduce total peripheral resistance and lower blood pressure. Indications for hypertension, especially for hypertensive patients with coronary heart disease. It can be used to treat coronary heart disease and high blood pressure, and can also be used for congestive heart failure. The half-life of nitrendipine is very short. After oral administration of 30 mg, the plasma concentration reaches its peak within 30 minutes. In plasma, its binding rate to plasma protein is about 98%. T 1 / 2 About ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/28A61K9/52A61K31/4422A61P9/12
Inventor 王颖侯峻冰
Owner 王颖
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