Method for treating inflammation of muscular skeleton and connective tissue

A connective tissue, inflammation technique with applications in the field of musculoskeletal and connective tissue inflammation

Inactive Publication Date: 2004-05-19
李毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because retinoic acid is a teratogen and has the mutagenic effects associated with this drug, it is used only in the treatment of severe acne that has not responded to other treatments

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] In 1988, a 62-year-old, generally healthy Caucasian male presented with an onset of joint disease affecting only the hands. The main site of disease was the distal interphalangeal joint (IP joint), which was fractured in 1980. Symptoms are edema and swelling with increasing tenderness over the years. The tenderness became so pronounced that in 1994 the patient was unable to wave his hand because of the pain. In addition, the patient had progressive fist-making disturbances due to swollen and tensed fingers.

[0035] X-ray examination revealed thinning of the joint cavity and swelling of the interphalangeal joint capsule. Laboratory tests were normal. The patient was diagnosed with osteoarthritis with tendonitis.

[0036] Several treatments for this patient had little or no effect, including aspirin (2-5 daily 325 mg pills); Motrin TM (ibuprofen) and Naprosyn TM (naproxen); and glucosamine / chondroitin sulfate.

[0037] In April 1997, the patient started taking Acc...

Embodiment 2

[0041] A 69-year-old retired naval warrant officer, Caucasian male, was diagnosed with inflammatory osteoarthritis and rheumatism. Its symptoms include joint pain lasting 6-10 years. Initially in 1992, the joint pain affected the patient's right buttock, and the patient suffered from hip pain while working. In 1994, the patient gradually developed neck and left shoulder pain. X-ray results showed calcification of the cervical spine. Additionally, the patient was diagnosed with a rotator cuff injury in the shoulder. In 1997, the patient developed tenderness in the hand while playing golf. Since then, the condition of the patient's hand has further deteriorated, with swollen fingers and difficulty in making a fist. However, the patient's blood biochemistry was normal.

[0042] Previous patients on aspirin and Motrin TM treatment, but with little effect. Treatment with glucosamine / chondroitin sulfate had only a transient effect. Physical therapy only partially relieved th...

Embodiment 3

[0046] A 61-year-old Caucasian male farmer presented with a 10+ year history of hand pain involving the fingers, with swollen and tender interphalangeal joints. Hand disorders can make work and golf difficult. He was diagnosed with osteoarthritis.

[0047]The patient started treatment with 13-cis retinoic acid in April 2001 with an initial dose of approximately 400 mg of Accutane per day  , for 21 days, followed by a maintenance dose of approximately 40 mg twice a week. After 10 weeks of treatment, the patient's symptoms began to improve, including a reduction in finger swelling and tenderness and an increase in range of motion. The improvement in symptoms was maintained with continuous administration of the maintenance dose for the subsequent 6 months.

[0048] The patient's blood test results were normal before and after treatment. Apart from dry skin and lips, the patient had no other side effects. These side effects disappeared after taking the maintenance dose.

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PUM

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Abstract

A method of treating said musculoskeletal and connective tissue inflammations including osteoarthritis and associated articular and periarticular inflammations, and non-articular Rheumatism including capsulitis, tendonitis, fibrositis, and perarticular inflammations is disclosed. The method includes administering to a patient of a therapeutically effective amount of a composition comprising 13-cis-retinoic acid. Preferably, the treatment method includes administering to a patient of an initial dosage of a composition comprising 13-cis-retinoic acid for an initial treatment period, and thereafter administering a maintenance dosage of the composition.

Description

technical field [0001] The present invention relates to a method of treating musculoskeletal and connective tissue inflammation. More specifically, the present method employs 13-cis retinoic acid to effectively treat musculoskeletal and connective tissue inflammation including osteoarthritis and joint and periarticular inflammation associated with osteoarthritis, and non-articular rheumatic diseases, which include bursitis, tendonitis, fibrositis, and periarticular inflammation. Background technique [0002] Musculoskeletal and connective tissue inflammation is a common disease affecting large numbers of people. Some common musculoskeletal and connective tissue inflammations include osteoarthritis and joint and periarticular inflammation associated with osteoarthritis, and non-articular rheumatic diseases, which include bursitis, tendonitis, fibrosis, and joint Peripheral inflammation. [0003] Osteoarthritis is one of the most common types of arthritis, more common in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/20A61K9/48A61K31/203A61P19/02A61P19/04A61P29/00
Inventor L·迪安·帕克斯
Owner 李毅
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