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Application of 6-methocy bideoxy bideoxy guanosine in preparation of antihepatitis B medicine

A methoxydideoxyguanosine, anti-hepatitis B technology, applied in the field of 6-methoxydideoxyguanosine, can solve the problem of blocking virus replication and so on

Inactive Publication Date: 2004-05-05
GUANGZHOU YIPINHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

But at the same time, ddGTP can also penetrate into the positive and negative strands like lamivudine, thereby blocking the replication of the virus

Method used

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  • Application of 6-methocy bideoxy bideoxy guanosine in preparation of antihepatitis B medicine

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Embodiment Construction

[0014] Below are some experiments done by the applicant on the antiviral effect and cytotoxicity of 6-methoxydideoxyguanosine in primary duck liver cells and Peking duck and woodchuck hepatitis B virus animal models:

[0015] 1. Determination of anti-hepatitis B virus activity in primary duck liver cells

[0016] Select the Peking duck congenitally infected with hepatitis B virus just 10 days after birth, take its liver and prepare hepatocytes, add 2×10 6 Hepatocytes, cultured in L-15 nutrient solution containing 5% bovine serum, cultured in 5% CO 2 In an incubator at 37°C, after the second day of cultivation, test compounds of different concentrations were added to the petri dish so that the final concentrations were 0, 0.1 μg / ml, 1 μg / ml, 10 μg / ml, and 100 μg / ml. The culture medium and test drug were changed every two days until the 16th day. Then add cell lysate to the culture dish to lyse the cells, add 200ug / ml protenase K to incubate for 1.5 hours, add the same volume ...

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Abstract

An application of 6-methoxy dideoxyguanosine in preparing the medicine to prevent and treat hepatitis B and liver cancers. It has high resistance to hepatitis B virus and its mutation strain.

Description

technical field [0001] The present invention relates to a new application of 6-methoxy dideoxyguanosine, specifically its application for anti-hepatitis B virus. Background technique [0002] Hepatitis B has been known as an infectious disease for thousands of years. Before the introduction of modern antiviral therapy, Chinese traditional Chinese medicine used astragalus, schisandra and Bupleurum to treat hepatitis and achieved certain anti-hepatitis B virus therapeutic effect. These drugs are still widely used in our country until today. [0003] Interferon is the first modern western medicine widely used to treat hepatitis B. Its mechanism of action is to stimulate oligoacetyl synthetase to inhibit the synthesis of viral proteins. Other anti-hepatitis B virus mechanisms are mainly to enhance the body's cellular immune function to kill infection Hepatocytes of hepatitis B virus achieve the purpose of inhibiting the replication of hepatitis B v...

Claims

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Application Information

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IPC IPC(8): A61K31/7064A61P1/16A61P31/12
Inventor 刘晓宇李战黄海燕陈静
Owner GUANGZHOU YIPINHONG PHARMA
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