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Externally applied medicine for treating women's inflammation and its prepn process

A technology for topical medicine and gynecological inflammation, applied in the field of medical preparations and preparations derived from plant materials, can solve the problems of low utilization rate of active ingredients of medicinal materials, waste of plant resources, unsatisfactory curative effect, etc.

Inactive Publication Date: 2004-04-07
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional Chinese medicines related to snow lotus in gynecology have also been developed, such as snow lotus capsules, snow lotus Shuyinjie, etc. These are composed of many medicinal materials, which are extracted with water or alcohol or directly crushed into powder for use, which will inevitably result in the active ingredients of the medicinal materials. Low utilization rate, waste of plant resources, and unsatisfactory curative effect

Method used

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  • Externally applied medicine for treating women's inflammation and its prepn process
  • Externally applied medicine for treating women's inflammation and its prepn process
  • Externally applied medicine for treating women's inflammation and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1 Take by weighing 1Kg of snow lotus, 4Kg of Sophora flavescens, 2Kg of Fructus Cnidii, 1Kg of Kochia scopariae and put in a 5LHA-9805 type supercritical extraction kettle to extract, extracting kettle, separating kettle I, separating kettle II, storage tank are respectively heated or Cooling, when the temperature of the extraction tank reaches 45°C, the temperature of the separation tank I is 60°C, and the temperature of the separation tank II is 40°C, turn on the CO 2 Steel cylinder, the system is pressurized by a high-pressure pump, and an appropriate amount of ethanol is injected as an entrainer. The pressure of the extraction kettle reaches 35Mpa, and the pressure of the separation kettle I is 14Mpa; when the pressure of the separation kettle II is 6Mpa, the extraction is circulated for 2 hours. After the extraction, Discharge at the discharge port of separation kettle I and separation kettle II respectively, and the extract is concentrated to obtain 240g...

Embodiment 2

[0075] Example 2 Weigh 1.5Kg of snow lotus, 3Kg of Sophora flavescens, 2Kg of Fructus Cnidii, and 1.5Kg of Kochia scopariae, put them in a Chinese medicine extraction pot, add 10 times the amount of water to decoct for 2 hours, filter, add 5 times the amount of water to decoct the dregs of the medicine After 1 hour, filter, and combine two times of decocting the filtrate, and the filtrate is vacuum-dried under reduced pressure (less than 0.1 MPa, temperature below 70° C.) and concentrated into 2.6 Kg of medicinal extract, and the weight loss on drying of the medicinal extract is 45%.

Embodiment 3

[0076] Embodiment 3, weigh 2Kg of Saussurea chinensis, 2Kg of Sophora flavescens, 1Kg of Fructus Cnidii, 3Kg of Fructus Kochia scoparia, put in the Chinese medicine extraction pot, add 10 times the amount of ethanol to reflux for 1 hour, filter, add ethanol to reflux for 1 hour with medicinal residues, filter, and combine Twice the filtrate, the filtrate was vacuum-dried under reduced pressure (vacuum degree below 0.1MPa, temperature below 70°C) and concentrated into an extract to obtain 1.7kg, and the loss on drying of the extract was 46%.

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Abstract

The present invention relates to plant medicine and its preparation process. The medicine consists of active components with or without pharmaceutically acceptable supplementary material. The active components include the supercritical CO2 extractive, alcohol extractive or water extractive of Saussurea involucrata in 1-3 weight portions, flavescent sophora root in 2-4 weight portions, cnidium fruit in 1-3 weight portions and broom cypress fruit in 0-3 weight portions. The externally applied medicine has excellent functions of resisting bacteria, resisting inflammation and resisting trichomonas. The medicine with supercritical CO2 extracted active components has ever higher treating effect.

Description

technical field [0001] The invention relates to a medicine for external use of gynecological inflammation and a preparation method thereof, and relates to a medical preparation derived from plant materials and a preparation method thereof. Background technique [0002] Common gynecological inflammations include vaginitis, urethritis, cervical erosion, genital itching, abnormal leucorrhea, etc. Most of them are caused by various bacterial or fungal infections. Currently, the commonly used chemical synthetic drugs for external use are mainly antibiotics. These drugs Although the effect is fast, many drugs can be absorbed through the vagina and cause certain toxic and side effects to the human body. Some drugs also have certain carcinogenic effects through animal experiments. When antibiotics are used for vaginitis, it is easy to change the vaginal flora, lead to flora imbalance, and induce superinfection. [0003] Traditional Chinese medicine is based on natural plants and ha...

Claims

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Application Information

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IPC IPC(8): A61P15/00A61P31/02
Inventor 葛发欢李菁刘菊妍杨敏黄晓芬史庆龙
Owner GUANGZHOU HANFANG PHARMA
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