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Prepration process for biologic hemostatic sponge material

A hemostatic sponge and biological technology, applied in the field of preparation of medical biological hemostatic materials, can solve the problems of mechanical performance, antibacterial performance defects, complex production process of hemostatic sponge, poor adhesion of wound tissue, etc., and achieves wide application value and good biological phase. Capacitive, low-cost effect

Inactive Publication Date: 2004-03-31
北京益而康生物工程有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, a collagen and gelatin hemostatic sponge is used in the prior art, but the production process of the hemostatic sponge is complicated, the cost is high, the adhesion to the wound tissue is poor, and there are still defects in aspects such as mechanical properties and antibacterial properties.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Chitosan with a degree of deacetylation of 50% and a molecular weight of 10,000 Daltons was dissolved in a 0.1M hydrochloric acid solution to prepare a 1% chitosan solution, statically defoamed, packaged in containers, and freeze-dried , made into a sponge layer with a thickness of 1 mm; soaked in ammonia water / ethanol (7:3) for 5 minutes, and rinsed with distilled water. Then freeze-dried, Co 60 Disinfection and spare.

Embodiment 2

[0024] Chitosan with a degree of deacetylation of 70% and a molecular weight of 50,000 Daltons was dissolved in 1% acetic acid, defoamed in vacuum, packaged in containers, lyophilized to form a sponge layer with a thickness of 2 mm, and treated with ammonia water. After soaking for 15 minutes, rinse with distilled water. Then freeze-dried, Co 60 Disinfection and spare.

[0025] In use, a small amount of 1% chitosan acetic acid (adjust the pH of the solution to about 5 with sodium bicarbonate solution) can be applied to the attachment surface of the chitosan sponge to enhance the adhesion and hemostatic effect of the chitosan sponge.

Embodiment 3

[0027] Dissolve chitin with a degree of deacetylation of 20% and a molecular weight of 100,000 Daltons in a mixed solvent of trichloroacetic acid / chlorinated hydrocarbon (3:1) to make a chitin solution with a concentration of 1%, and remove air bubbles. , packaged in a container, then added 0.5% fibrinogen and 1% sorbitol in a weight ratio, freeze-dried to make a 3mm thick sponge layer, soaked in ammonia water / methanol (7:1) for 5 minutes, distilled water Rinse, then freeze-dried, Co 60 Disinfection and spare.

[0028] In use, the sponge layer can be directly attached to the wound, and the sponge can be pressed with tweezers.

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Abstract

A method of producing biological hemostasis spongy material. It comprises: taking chitosan / chitin as the main raw material, preparing the solution, defoaming and putting into a container and freeze-drying, forming a spongy layer with the thickness of 1-10mm; soaking with ammonia, ammonia / alcohol, ammonia / acetone, ammonia / methanol, washing with distilled water, freeze-drying and disinfecting. Theprepared hemostasis spongy material has abilities of stanching bleeding and promoting tissue rehabilitation.

Description

technical field [0001] The invention relates to a preparation method of a medical biological hemostatic material, and belongs to the technical field of medical material preparation. Background technique [0002] Chitin, also known as chitosan, chitin, chitin, chitin, shell protein, etc., is a linear amino polysaccharide insoluble in water, alkali and conventional solvents that maintains and protects the bodies of crustaceans and microorganisms. Widely present in the wings or shells of arthropods (arachnids, crustaceans) and the cell walls of fungi and algae (Chen Tian, ​​Yan Jun, Xu Rongnan, Xia Yan. Journal of Biomedical Engineering, 1989; 6(1) : 60.), the annual biosynthesis is nearly one billion tons, and only 10% to 30% of the crustacean waste after processing aquatic products such as crabs and shrimps. It is a kind of natural resource with potential value yet to be exploited. Acid-soluble chitosan (Chitosan) is a deacetylated compound of chitin, a derivative of chitin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28
Inventor 王小红刘军朵
Owner 北京益而康生物工程有限公司
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