Automatic liposome preparation apparatus and method for prepaving liplsome by same
A liposome and lipid technology, applied in the field of medicine, can solve problems such as it is difficult to encapsulate an effective amount of drugs, and achieve the effects of controllable size, reduction of intermediate processes, and narrow particle size distribution
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 2
[0092] Embodiment 2: Use the automated liposome preparation device of the present invention to prepare liposomes that can be used for pH gradient method to encapsulate medicines with a particle size of 100nm
[0093] The liposome prepared by the device of the present invention can be used to encapsulate all medicines that can be encapsulated by the traditional pH gradient method, and only the preparation of liposome doxorubicin is used as an example for verification.
[0094] Name
molecular weight
Mole (%)
Feed amount (g)
760
60
18.24
386.7
39
6.03
Vitamin E
472
1
0.19
[0095] Add the prescribed amount of lecithin, cholesterol and vitamin E to 20ml of ethanol, heat to 45°C and stir to dissolve it completely, then add it to the organic liquid storage tank, add 180ml of 400mM, pH4 tartaric acid solution to the aqueous solution storage tan...
Embodiment 3
[0097] Embodiment 3: use novel automatic liposome preparation device to prepare fat-soluble drug liposome
[0098] The device of the present invention can be used to prepare all fat-soluble drug liposomes, and only the preparation of liposome miconazole is used as an example for verification.
[0099] Name
molecular weight
Mole (%)
Feed amount (g)
760
87
19
386.66
9.2
1.0
479.15
15.0
2.5
282
15
0.3
281
0.1
0.01
Vitamin E
472
0.2
0.03
peppermint oil
·
0.2
0.3
[0100] Add 40ml of ethanol to lecithin, cholesterol, oleic acid, miconazole nitrate, azone, vitamin E and peppermint oil, heat to 45°C and stir to dissolve completely, then add to the organic liquid storage tank, add 180ml o...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com