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Preparing method for sustained releasing huperzine preparation

A sustained-release preparation, huperzine technology, applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the effect of drug efficacy, patients cannot remember the time of taking medicine, and it is difficult to grasp the time and frequency of taking medicine and other issues, to achieve the effect of good feasibility and reliable drug treatment

Inactive Publication Date: 2003-11-19
解健博
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For Alzheimer's patients with cognitive impairment and memory loss, it can be difficult to know when and how often to take medication
Some patients forget whether they have taken the medicine, some patients can't remember the time of taking the medicine, and some patients can't take it according to the requirements of the doctor and the medicine.
As a result, the efficacy of the drug is affected, thereby affecting the patient's recovery and treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Huperzine water-soluble matrix sustained-release tablet, the weight of a single tablet is 300 mg.

[0021] Component weight percent: drug huperzine A 0.1-0.4, rate-controlling part adopts hydroxypropyl methylcellulose 15, excipient adopts micropowder silica gel 0.5, magnesium stearate 0.5, microcrystalline cellulose 30.0 and lactose 53.9- 53.6, a total of 100.0%.

[0022] The specific steps are as follows: weigh each component according to the above prescription. Take huperzine A, mix with microcrystalline cellulose for 10 minutes, add hydroxypropyl methylcellulose, lactose and micropowder silica gel and mix for another 10 minutes, add magnesium stearate and mix for 5 minutes. Transfer the mixed granules to the feed hopper of the tablet machine and adjust the tablet weight regulator so that the tablet weight is about 300 mg. Get this tablet 500 grams, to small-sized coating machine, with 10% coating powder solution coating, when treating that tablet weig...

Embodiment 2

[0023] Embodiment 2: Huperzine B matrix sustained-release tablet, the weight of a single tablet is 300 mg.

[0024] Component weight percentage: drug huperzine B 0.1-0.4, 0.25 can be selected, hydroxypropyl methylcellulose 20 is used for the speed control part, micronized silica gel 0.5 is used as excipient, magnesium stearate 0.5, microcrystalline cellulose 30.0 And lactose 51.1%-50.8, a total of 100.0%.

[0025] The specific steps are as in "Example 1"

Embodiment 3

[0026] Example 3: Melaleuca extract matrix sustained-release tablet, the weight of a single tablet is 300 mg.

[0027] Component weight percentage: melaleuca extract (Hupermus serrata) 1-4, 2.5 can be selected, hydroxypropyl cellulose 20.0 is used for the speed control part, micronized silica gel 0.5 is used as excipient, magnesium stearate 0.5, lactose 70 -75, a total of 100.0%.

[0028] The specific steps are as in "Example 1"

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PUM

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Abstract

A slowly releasing huperzine for treating sanile dementia by oral application features that its active components are huperzine A and its humolog, or their salts or ester derivatives. Its advantages are slow release (more than 12 hr), and high curative effect and safety.

Description

Technical field: [0001] The invention relates to a preparation method of an oral sustained-release and controlled-release pharmaceutical preparation, specifically a preparation method for making huperzine and its homologue into a sustained-release or controlled-release preparation. Background technique: [0002] Dementia is one of the most common geriatric diseases. Alzheimer's Disease (Alzheimer'sDisease) is the most common type of Alzheimer's disease, and its pathogenesis is still under study. In short, the patient's brain is responsible for controlling memory and reasoning. of gradual decline. Another relatively common type of Alzheimer's disease is vascular dementia, which is more common in the north. In addition to the above two types, there is another type called mixed dementia. [0003] According to the standards of the United Nations, 11% of our country's population is currently aged. It is expected to exceed 400 million by the middle of the 21st century. Statis...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/28A61K31/132A61K31/44A61K47/12A61K47/14A61K47/36A61K47/44A61P25/28
Inventor 解健博
Owner 解健博
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