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Domperidone oral disintegrating tablet and preparation process thereof

A technology of domperidone and orally disintegrating tablets, which is applied in the direction of pill delivery, digestive system, drug combination, etc., can solve problems such as bad smell, delaying the best time for treatment, affecting rest, etc., achieving unique formula, good promotion prospects, and avoiding repetition The effect of investment

Inactive Publication Date: 2003-10-22
江西省药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to drinking too much water and affect the night's rest
In addition, the bitter taste and bad smell of many oral medicines are often unacceptable, causing some patients to avoid taking the medicine and refusing treatment, thus delaying the best time for treatment. Orally disintegrating tablets solve these problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The formulation of the present invention consists of the following components in parts by weight

[0021] Domperidone 10.00g

[0022] Microcrystalline cellulose 21.00g

[0023] Mannitol 15.60g

[0024] Cross-linked polyvinylpyrrolidone 12.00g

[0025] Aspartame 0.3g

[0026] Micro powder silica gel 0.8g

[0027] Magnesium stearate 0.3g

[0028] 1000 pieces in total

[0029] The dosage form can be produced using conventional tablet pharmaceutical equipment and prepared by a compression process. The specific preparation method is as follows: crush aspartame and domperidone through an 80 mesh sieve, weigh according to the prescription, and mix well and then micro The crystalline cellulose, mannitol, cross-linked polyvinylpyrrolidone, micro-powdered silica gel, and magnesium stearate were passed through an 80-mesh sieve, respectively weighed according to the prescription, mixed evenly, and then mixed with domperidone mixed with aspartame, and sieved Mix well, detect the content...

Embodiment 2

[0031] The formulation of the present invention consists of the following components in parts by weight

[0032] Domperidone 10.00g

[0033] Microcrystalline cellulose 19.00g

[0034] Mannitol 14.40g

[0035] Sodium carboxymethyl starch 15.00g

[0036] Aspartame 0.3g

[0037] Micro powder silica gel 1.0g

[0038] Magnesium stearate 0.3g

[0039] 1000 pieces in total

[0040] The dosage form can be produced using conventional tablet pharmaceutical equipment and prepared by a compression process. The specific preparation method is as follows: crush aspartame and domperidone through an 80 mesh sieve, weigh according to the prescription, and mix well and then micro The crystalline cellulose, mannitol, sodium carboxymethyl starch, micronized silica gel, and magnesium stearate were passed through an 80-mesh sieve, respectively, and weighed according to the prescription, mixed uniformly, and then mixed with domperidone mixed with aspartame, and sieved Mix well, detect the content of inte...

Embodiment 3

[0042] The formulation of the present invention consists of the following components in parts by weight

[0043] Domperidone 10.00g

[0044] Microcrystalline cellulose 14.60g

[0045] Mannitol 22.00g

[0046] Croscarmellose Sodium 12.00g

[0047] Aspartame 0.3g

[0048] Micro powder silica gel 0.8g

[0049] Magnesium stearate 0.3g

[0050] 1000 pieces in total

[0051] The dosage form can be produced using conventional tablet pharmaceutical equipment and prepared by a compression process. The specific preparation method is as follows: crush aspartame and domperidone through an 80 mesh sieve, weigh according to the prescription, and mix well and then micro The crystalline cellulose, mannitol, sodium carboxymethyl cellulose, micronized silica gel, and magnesium stearate were passed through an 80-mesh sieve, respectively, and weighed according to the prescription, mixed uniformly, and then mixed with domperidone mixed with aspartame. Sieve and mix well, detect the content of intermed...

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PUM

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Abstract

The present invention provides a domperiodone oral disitegrant tablet preparation. Its composition includes medicine active component, filling agent, corrective, disitegrant, lubricating agent and glidant. Its medicin active component includes dopamine receptor antagonist and gastroprokinetic, and its disitegrant agent is selected from cross-linked polyvinylpyrrolidone, carboxymethyl starch sodium and microcrystal cellulose or their mixture, and corrective is selected from aspartame. Said invention adopts direct addition of disitegrant in theprescription so as to attain the effect of quick disitegration. Its preparation process is simple, and it is convenient for taking in.

Description

Technical field [0001] The invention relates to an oral pharmaceutical dosage form which can be used as a gastrodynamic drug which can quickly disintegrate and mask the bitter taste, in particular to a domperidone orally disintegrating tablet preparation and a preparation method thereof. Background technique [0002] Domperidone (Domperidone), the chemical name is 5-chloro-1-(1-[3-(2,3dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidyl }-1,3-dihydro-2H benzimidazole-2-one, a peripheral dopamine receptor blocker, is an effective drug for the treatment of indigestion caused by delayed gastric emptying, gastroesophageal reflux, and esophagitis. In recent years Since its clinical application has developed rapidly and has great safety, it has been listed as an OTC drug. The digestive ability and the resistance of the digestive tract of the elderly have decreased. It is very effective to take this product in the case of poor digestive motility. It is also very effective for the trea...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/454A61P1/04A61P1/14
Inventor 曾文丽陈梅荣庄妍胡健刘良玉
Owner 江西省药物研究所
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