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Surface active strong internal fixed titanium bone connection plate and its making method

A technology of surface activity and manufacturing method, which is applied in the direction of fixator, internal bone synthesis, external plate, etc., can solve the problems affecting the performance of internal fixation bone plate, poor wollastonite coating and osseointegration ability, etc., to achieve excellent Biological properties, easy industrial production, and easy-to-obtain effects

Inactive Publication Date: 2003-09-17
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the bone-bearing replacement material prepared by the above method has a bonding strength of 35-42 MPa between the substrate and the coating, it still cannot fully meet the requirements for use as an internal fixation bone plate. In addition, the bonding ability of the wollastonite coating to bone is insufficient. Good, directly affects the performance of the internal fixation plate

Method used

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  • Surface active strong internal fixed titanium bone connection plate and its making method
  • Surface active strong internal fixed titanium bone connection plate and its making method
  • Surface active strong internal fixed titanium bone connection plate and its making method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Alkali treatment-heat treatment two-step method to manufacture titanium substrate surface coverage can form TiO 2 gel porous TiO 2 internal fixation plate

[0059] (1) Alkali treatment

[0060] Soak the finely processed medical titanium bone plate matrix in NaOH solution with a temperature of 60°C and a concentration of 8 moles for 12 hours, so that the surface of the matrix will generate NaOH. 2 TiO 3 layer.

[0061] (2) Cleaning and drying

[0062] After alkali treatment, the surface is covered with Na 2 TiO 3 The layered titanium bone plate matrix is ​​washed with distilled water and allowed to dry naturally, and a porous TiO layer with a thickness of about 6 microns can be formed on the surface of the titanium matrix 1. 2 Layer 3, such as figure 1 , figure 2 shown.

[0063] (3) heat treatment

[0064] Cover the dried surface with porous TiO 2 The layered titanium bone plate matrix is ​​placed in a heat treatment device, and the temperature is...

Embodiment 2

[0065] Example 2: Acid-alkali two-step treatment method to manufacture titanium substrate surface covering can form TiO 2 gel porous TiO 2 internal fixation plate

[0066] (1) acid treatment

[0067] The treatment solution is prepared by 98% sulfuric acid, 36% hydrochloric acid and deionized water, sulfuric acid: hydrochloric acid: deionized water = 1:1:2, and the finished medical titanium bone plate base is treated at room temperature (20°C). 1 Soak in the above treatment solution for 60 minutes, then take it out and wash it with deionized water.

[0068] (2) Alkali treatment

[0069] Put the acid-treated titanium bone plate base 1 in a NaOH solution with a temperature of 150°C and a concentration of 0.2 moles and boil for 4 hours, then take it out and wash it with water, and after natural drying, a 5-micron-thick layer can be formed on the surface of the titanium base. Porous TiO 2 Layer 3, such as figure 1 , figure 2 shown.

Embodiment 3

[0070] Example 3: Manufacture of titanium alloy substrate surface coverage by anodic oxidation treatment can form TiO 2 gel porous TiO 2 internal fixation plate

[0071] (1) Anodizing treatment

[0072] The electrolyte is 1 molar H 2 SO 4 , at room temperature (20° C.), place the finished medical titanium alloy bone plate base 1 in an electrolysis device for anodic oxidation treatment, and pass a 150V direct current for 60 seconds.

[0073] (2) heat treatment

[0074] Put the titanium alloy bone plate substrate 1 after anodic oxidation treatment into the heat treatment equipment, carry out temperature program (such as 5°C / min) to 600°C and keep it warm for 60 minutes, then turn off the power and cool to room temperature with the furnace, and the titanium alloy substrate can be Porous TiO with a thickness of about 5 microns is formed on the surface 2 Layer 3, such as figure 1 , figure 2 shown.

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Abstract

A high-strength internally fixing bone-setting Ti plate with surface activity has a basal body of medical Ti or Ti alloy and a bioactive layer on the surface of the said basal body. The bioactive layer may be porous TiO2 layer, TiO2-phosphorite layer, rutile-type TiO2 layer, or hydroxy phosphorite layer, which can generate TiO2 gel. The above-mentioned bone-setting Ti plate is prepared by alkali treating-heat treating method, acid-alkali treating method, anodizing method, etc.. Its advantages are high biologic performance, high binding strength to bone, and speeding up the healing of bone fracture.

Description

1. Technical field [0001] The invention belongs to the field of biomaterials, and in particular relates to a strong internal fixation bone plate for bone trauma surgery, repair and reconstruction surgery, and plastic surgery and a manufacturing method thereof. 2. Background technology [0002] The existing fracture internal fixation materials are titanium splints, which are most widely used. However, titanium splints are mainly focused on the shape and structure design, and most of them have not been modified on the surface. They cannot meet the requirements of matte surgical devices, let alone achieve surface bioactivity. For example: "Titanium plate for skull defect repair" with application number 00240389 and approval announcement number 2452458; "Titanium alloy small splint for chin" with application number 01106471 and approval announcement number 2507426, etc. There are also some patents on the surface treatment of titanium matrix materials. For example, the Chinese pa...

Claims

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Application Information

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IPC IPC(8): A61B17/80A61L27/06A61L27/12A61L31/02
Inventor 包崇云刘晓光曹阳杨帮成李旭东张兴栋
Owner SICHUAN UNIV
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